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Gammaherpesvirus infections in equids: a review

Authors Marenzoni M, Stefanetti V, Danzetta ML, Timoney PJ

Received 12 January 2015

Accepted for publication 24 February 2015

Published 1 April 2015 Volume 2015:6 Pages 91—101


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Takashi Agui

Maria Luisa Marenzoni,1 Valentina Stefanetti,1 Maria Luisa Danzetta,1 Peter Joseph Timoney2

1Department of Veterinary Medicine, University of Perugia, Perugia, Italy; 2Department of Veterinary Science, Maxwell H Gluck Equine Research Center, Lexington, KY, USA

Abstract: Although the first equine gammaherpesvirus was identified over 50 years ago, the isolation and characterization of other members of this virus group has been relatively recent. Even so, numerous clinical syndromes have been identified in equid species in association with these viruses. Equid gammaherpesviruses are a genetically heterogeneous viral subfamily, the function of which in host immune modulation and disease pathogenesis has not yet been elucidated. While they share similarities with gammaherpesviruses in humans, the role they play in their relationship with the host is the subject of continued interest and research. Their widespread presence in horses and other equid species provides a considerable challenge in linking them with particular clinical and pathological conditions and in defining their significance from a diagnostic and therapeutic viewpoint. The present review provides an update on the taxonomy, epidemiology, and clinical syndromes, especially respiratory, reported in association with gammaherpesvirus infection in horses, donkeys, and other equid species.

Keywords: equid gammaherpesviruses, horses, donkeys, other equid species, equine multinodular pulmonary fibrosis

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