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Functions and mechanisms of long noncoding RNAs in lung cancer

Authors Peng Z, Zhang C, Duan C

Received 30 March 2016

Accepted for publication 12 June 2016

Published 20 July 2016 Volume 2016:9 Pages 4411—4424

DOI https://doi.org/10.2147/OTT.S109549

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Jianmin Xu


Zhenzi Peng, Chunfang Zhang, Chaojun Duan

Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, People’s Republic of China

Abstract: Lung cancer is a heterogeneous disease, and there is a lack of adequate biomarkers for diagnosis. Long noncoding RNAs (lncRNAs) are emerging as an important set of molecules because of their roles in various key pathophysiological pathways, including cell growth, apoptosis, and metastasis. We review the current knowledge of the lncRNAs in lung cancer. In-depth analyses of lncRNAs in lung cancer have increased the number of potential effective biomarkers, thus providing options to increase the therapeutic benefit. In this review, we summarize the functions, mechanisms, and regulatory networks of lncRNAs in lung cancer, providing a basis for further research in this field.

Keywords: ncRNA, tumorigenesis, biomarker, network, proliferation, apoptosis
 

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