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Foxj2 overexpression is associated with poor prognosis, progression, and metastasis in nasopharyngeal carcinoma

Authors Shan Y, Chang T, Shi S, Tang M, Bao L, Li L, You B, You Y

Received 16 February 2017

Accepted for publication 19 April 2017

Published 24 July 2017 Volume 2017:10 Pages 3733—3741


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 3

Editor who approved publication: Dr Yao Dai

Ying Shan,1,* Tao Chang,2,* Si Shi,1 Mingming Tang,3 Lili Bao,1 Li Li,1 Bo You,1 Yiwen You1

1Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, 2Department of Otorhinolaryngology, Head and Neck Surgery, The First People’s Hospital of Wujiang, Wujiang, 3Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of China

*These authors contributed equally to this work

Abstract: Foxj2, a novel member of Forkhead box family, has been reported to play an important role in tumorigenesis, progression, and metastasis of certain cancers. However, the expression status and effects of Foxj2 on nasopharyngeal carcinoma (NPC) progression and metastasis remain debated. In this study, we first examined the expression of Foxj2 in NPC by immunohistochemistry and Western blotting analysis. We confirmed significantly elevated expression of Foxj2 in NPC tissues and cell lines. Next, the relationships between Foxj2 expression levels and the clinicopathological factors were investigated. Its expression level correlated with T-classification (P=0.026), distant metastasis (P=0.004), and clinical stage (P=0.029). In addition, high expression of Foxj2 was associated with poor prognosis in NPC patients. The effects of Foxj2 on cell proliferation and migration were explored by RNA interference (RNAi) with CCK-8 assay, cell cycle analyses, wound healing, and transwell assay. In conclusion, our data indicate that Foxj2 upregulation promotes the progression and migration of NPC. It makes Foxj2 serve as a potential therapeutic target for the treatment of NPC.

Keywords: Foxj2, nasopharyngeal carcinoma, prognosis, progression, migration

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