Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow
Authors Yılmaz M, Dağlı MN, Uku Ö, Bilen MN, Korkmaz H, Erdem K, Kurtoğlu E
Received 29 October 2016
Accepted for publication 24 March 2017
Published 7 July 2017 Volume 2017:13 Pages 255—261
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Dr Daniel Duprez
Mücahid Yılmaz,1 Mustafa Necati Dağlı,2 Ökkeş Uku,1 Mehmet Nail Bilen,1 Hasan Korkmaz,2 Kenan Erdem,3 Ertuğrul Kurtoğlu1
1Department of Cardiology, Elazığ Education and Research Hospital, 2Department of Cardiology, FIRAT University School of Medicine, Elazığ, 3Department of Cardiology, Sivas Hospital State, Sivas, Turkey
Background: The relationship between increased mean platelet volume (MPV) and atherosclerosis is well known. In the present study, MPV in patients with coronary slow flow (CSF) and in cases with normal coronary anatomy (NCA) was investigated and compared with the aim of identifying the relationship between CSF and MPV.
Patients and methods: We studied 40 patients previously determined via coronary angiography as having NCA and 40 patients with CSF in the coronary blood stream, as identified by thrombolysis in myocardial infarction square. Thus, a total of 80 patients from the Elaziğ Education and Research Hospital (Elaziğ, Turkey) were included in the present study retrospectively and laboratory and anamnesis information was scanned into their files. The relationship between MPV and CSF was studied.
Results: MPV levels were observed to be significantly higher in the CSF group compared to the NCA group (10.05±1.3 and 8.6±0.6, p<0.001). In receiver operating characteristics analyses, it was determined that an MPV >9.05 measured in CSF patients at application had a predictive specificity of 77.5% and sensitivity of 77.5% for CSF (area under the curve: 0.825, 95% confidence interval [CI]: 0.726–0.924, p<0.0001). It was found that MPV level was an independent predictor of CSF (β=−600, p<0.001, 95% CI: −0.383 to −0.176).
Conclusion: MPV is increased in patients with CSF when compared to patients with NCA. This finding supports the fact that MPV could be a predictor of CSF.
Keywords: coronary slow flow, mean platelet volume, atherosclerosis
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