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Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes

Authors Reynolds J

Published 30 July 2009 Volume 2009:2 Pages 127—134

DOI https://doi.org/10.2147/DMSO.S4637

Review by Single-blind

Peer reviewer comments 3


Jonathan K Reynolds

Washington State University, College of Pharmacy, Pullman, WA, USA

Abstract: JanumetTM, a fixed dose combination of sitagliptin/metformin HCL manufactured by Merck Pharmaceuticals, has received US Food and Drug Administration approval for treatment of patients with type 2 diabetes, that are inadequately controlled, either by sitagliptin or metformin alone or together in free-dose combination form. Sitagliptin, an inhibitor of the enzyme DDP-4, assists patients with type 2 diabetes mellitus to achieve glycemic control. It has been shown to be safe and effective at 100 mg daily doses. The effect of giving sitagliptin in combination with metformin is thought to have a complimentary and possibly additive effect on glycemic control.

Keywords: sitagliptin, metformin, fixed-dose combination, dipeptidyl peptidase-4 inhibitor, DPP-4 inhibitor

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