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Fixed Cutaneous Sporotrichosis Due to Sporothrix globosa

Authors Liu F, Liu Y, Yuan N, Zhang X, Cao M, Dong J, Zhang J

Received 3 November 2020

Accepted for publication 10 January 2021

Published 25 January 2021 Volume 2021:14 Pages 91—96


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Jeffrey Weinberg

Fang Liu,1 Yingmei Liu,2 Na Yuan,1 Xiuying Zhang,1 Mei Cao,1 Jie Dong,1 Jinqing Zhang1

1Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China; 2Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China

Correspondence: Fang Liu
Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South Road, Beijing 100020, People’s Republic of China
Tel +86-18611369216

Purpose: This report describes a case of a skin sporotrichosis infection and the steps taken to identify an effective antifungal treatment.
Patients and Methods: A 50-year-old woman from Jilin province, China, presented complaining of a small mass that had been on her right upper eyelid for two years. A skin biopsy was taken and submitted for bacterial and mycological assessment. Bacterial culture from the lesion was negative, but a fungal culture was positive. In vitro susceptibility test was performed to assess its susceptibility to antifungal drugs.
Results: The skin biopsy showed infectious granuloma. Fungal culture was identified as Sporothrix globosa based on both the morphological features and confirmation by the molecular method; it was resistant to many kinds of antifungal drugs, including amphotericin B, voriconazole, fluconazole, and caspofungin. However, it was relatively sensitive to itraconazole. The patient was prescribed 0.2 g itraconazole to be taken twice per day. One month later, she had almost completely recovered from her symptoms. The treatment lasted for 3 months and her liver function and renal function were normal at the endpoint.
Conclusion: Itraconazole was an effective treatment in this case of a multidrug-resistant sporotrichosis caused by S. globosa.

Keywords: fixed cutaneous sporotrichosis, Sporothrix globosa

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