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Fish skin acellular dermal matrix: potential in the treatment of chronic wounds

Authors Patel M, Lantis JC II

Received 12 October 2018

Accepted for publication 14 February 2019

Published 12 July 2019 Volume 2019:6 Pages 59—70

DOI https://doi.org/10.2147/CWCMR.S157211

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 4

Editor who approved publication: Professor Marco Romanelli


Munir Patel, John C Lantis II

Department of Vascular Surgery, Mount Sinai St. Luke’s-West Hospital Center, New York, NY, USA

Abstract: The role of cellular and tissue-based therapies (CTPs) in the treatment of chronic wounds continues to grow. However, the utility of these is only partially investigated and very few head-to-head studies exist. In general, the ideal CTP would provide a structural matrix which would allow for dermal and epidermal regeneration with a single application. At present, this Holy Grail is very far from where we are. However, new CTPs continue to be designed with the goal of wound closure in mind. Acellular fish skin (AFS) is one such therapy. The histologic features make it amenable to cellular modulation, and its ability to provide omega-3 fatty acids to the local tissue makes it an unprecedented anti-inflammatory, antibacterial, antiviral, and analgesic component. There is burgeoning research on AFS that continues to validate its efficacy, although, much more substantial data will be required before its general acceptance. In this review, we will go through the current literature to evaluate the strengths and gaps in our current knowledge with the goal of providing a context for use in modern clinical practice.

Keywords: fish skin, chronic wounds, dermal matrix

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