Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
Received 20 November 2018
Accepted for publication 12 February 2019
Published 10 April 2019 Volume 2019:12 Pages 469—476
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Andrew Yee
Peer reviewer comments 2
Editor who approved publication: Professor Ming-Hui Zou
Dongseong Shin,1,2 Young Sil Eom, 3,4 Suk Chon,5 Byung-Joon Kim, 3,4 Kyung-Sang Yu,6,* Dae Ho Lee 3,4,*
1Department of Pharmacology, Gachon University College of Medicine, Incheon, Korea; 2Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea; 3Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea; 4Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea; 5Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea; 6Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea
*These authors contributed equally to this work
Background and objective: The effects of age and related factors on insulin sensitivity have not been definitively evaluated in East Asian populations. We proposed a reference range for the glucose disposal rate (M-value) on hyperinsulinemic-euglycemic study and its association with other parameters.
Methods: Healthy, non-diabetic young (n=10) and elderly (n=13) male subjects with normal body mass index were eligible for this study. Subjects who passed the oral glucose tolerance test (OGTT) underwent hyperinsulinemic-euglycemic clamp with high-dose (80 mU/m2·min) insulin infusion.
Results: M-values were normalized to body weight (MBW) and fat-free mass (MFFM). Neither M-value was significantly different between age groups (P=0.458 and P=0.900, respectively). An inverse correlation was observed between MFFM and baseline insulin (r=−0.418; P=0.047), baseline C-peptide (r=−0.426; P=0.043) and OGTT 2-hour glucose (r=−0.452; P=0.030). Regarding correlations with other insulin sensitivity indices, M-values were positively associated with the Matsuda index but not with homeostasis model assessment of insulin resistance.
Conclusion: Our results suggest that age is not a critical determinant of insulin sensitivity, while fasting insulin and C-peptide levels, OGTT 2-hour glucose level, and Matsuda index are predictable markers of insulin sensitivity in healthy Koreans.
Keywords: insulin sensitivity, hyperinsulinemic-euglycemic clamp, glucose disposal rate, age, Matsuda index
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