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Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects

Authors Shin D, Eom YS, Chon S, Kim BJ, Yu KS, Lee DH

Received 20 November 2018

Accepted for publication 12 February 2019

Published 10 April 2019 Volume 2019:12 Pages 469—476

DOI https://doi.org/10.2147/DMSO.S195350

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Dongseong Shin,1,2 Young Sil Eom, 3,4 Suk Chon,5 Byung-Joon Kim, 3,4 Kyung-Sang Yu,6,* Dae Ho Lee 3,4,*

1Department of Pharmacology, Gachon University College of Medicine, Incheon, Korea; 2Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea; 3Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea; 4Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea; 5Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea; 6Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea

*These authors contributed equally to this work

Background and objective: The effects of age and related factors on insulin sensitivity have not been definitively evaluated in East Asian populations. We proposed a reference range for the glucose disposal rate (M-value) on hyperinsulinemic-euglycemic study and its association with other parameters.
Methods: Healthy, non-diabetic young (n=10) and elderly (n=13) male subjects with normal body mass index were eligible for this study. Subjects who passed the oral glucose tolerance test (OGTT) underwent hyperinsulinemic-euglycemic clamp with high-dose (80 mU/m2·min) insulin infusion.
Results: M-values were normalized to body weight (MBW) and fat-free mass (MFFM). Neither M-value was significantly different between age groups (P=0.458 and P=0.900, respectively). An inverse correlation was observed between MFFM and baseline insulin (r=−0.418; P=0.047), baseline C-peptide (r=−0.426; P=0.043) and OGTT 2-hour glucose (r=−0.452; P=0.030). Regarding correlations with other insulin sensitivity indices, M-values were positively associated with the Matsuda index but not with homeostasis model assessment of insulin resistance.
Conclusion: Our results suggest that age is not a critical determinant of insulin sensitivity, while fasting insulin and C-peptide levels, OGTT 2-hour glucose level, and Matsuda index are predictable markers of insulin sensitivity in healthy Koreans.

Keywords: insulin sensitivity, hyperinsulinemic-euglycemic clamp, glucose disposal rate, age, Matsuda index


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