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Extended-release morphine sulfate in treatment of severe acute and chronic pain

Authors Balch RJ, Trescot A

Published 21 September 2010 Volume 2010:3 Pages 191—200


Review by Single anonymous peer review

Peer reviewer comments 6

Robert J Balch, Andrea Trescot
Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA USA

Abstract: Morphine is the archetypal opioid analgesic. Because it is a short-acting opioid, its use has been limited to the management of acute pain. The development of extended-release formulations have resulted in the increased utilization of morphine in chronic pain conditions. This review documents the history of morphine use in pain treatment, and describes the metabolism, pharmacodynamics, formulations, and efficacy of the currently available extended-release morphine medications.

Keywords: Morphine ER, sustained-release morphine, MSContin, Oramorph®, Kadian®, Avinza®, Embeda®

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