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Expression and functional characterization of FOXM1 in non-small cell lung cancer

Authors Zhang Y, Qiao W, Shan L

Received 14 January 2018

Accepted for publication 7 April 2018

Published 11 June 2018 Volume 2018:11 Pages 3385—3393

DOI https://doi.org/10.2147/OTT.S162523

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 3

Editor who approved publication: Dr Yao Dai


Yan Zhang, Wen-bin Qiao, Li Shan

Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Xinjiang, People’s Republic of China

Objectives: FOXM1 is a key member of the FOX transcription factor family, which plays a vital role in a series of physiological processes. In the present study, non-small cell lung cancer (NSCLC) patients and cell lines were studied to explore the correlation between FOXM1 expression and this malignancy.
Materials and methods: The expression status of FOXM1 was detected in 128 cases of NSCLC tissues and NSCLC cell lines. The relationship of FOXM1 expression and clinicopathological features of NSCLC patients was evaluated by us. In addition, we also explored the biological functions of FOXM1 in NSCLC cell lines.
Results: The FOXM1 is highly expressed in NSCLC tissues and cell lines. FOXM1 expression was closely correlated with lymph node status and TNM stage. Cox regression analysis were performed to demonstrate the prognosis role of FOXM1.
Conclusion: FOXM1 conferred a proliferation and invasion advantage to NSCLC cell. The FOXM1 can be regarded as an important molecular marker in NSCLC prognosis.

Keywords:
non-small cell lung cancer, FOXM1, proliferation, prognosis

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