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Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds

Authors Mohandas A, Kumar PT S, Raja B, Lakshmanan V, Jayakumar R

Received 19 January 2015

Accepted for publication 5 March 2015

Published 1 October 2015 Volume 2015:10(Supplement 1 Challenges in biomaterials research) Pages 53—66

DOI https://doi.org/10.2147/IJN.S79981

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Webster


Annapoorna Mohandas,* Sudheesh Kumar PT,* Biswas Raja, Vinoth-Kumar Lakshmanan, Rangasamy Jayakumar

Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India

*These authors contributed equally to this work

Abstract: Alginate hydrogel/zinc oxide nanoparticles (nZnO) composite bandage was developed by freeze-dry method from the mixture of nZnO and alginate hydrogel. The developed composite bandage was porous with porosity at a range of 60%–70%. The swelling ratios of the bandages decreased with increasing concentrations of nZnO. The composite bandages with nZnO incorporation showed controlled degradation profile and faster blood clotting ability when compared to the KALTOSTAT® and control bandages without nZnO. The prepared composite bandages exhibited excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and methicillin resistant S. aureus (MRSA). Cytocompatibility evaluation of the prepared composite bandages done on human dermal fibroblast cells by Alamar assay and infiltration studies proved that the bandages have a non-toxic nature at lower concentrations of nZnO whereas slight reduction in viability was seen with increasing nZnO concentrations. The qualitative analysis of ex-vivo re-epithelialization on porcine skin revealed keratinocyte infiltration toward wound area for nZnO alginate bandages.

Keywords: alginate, hydrogel, ZnO nanoparticle, hemostatic, antimicrobial activity, wound healing

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