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Experimental human hookworm infection: therapeutic potential

Authors Gaze S

Received 23 December 2015

Accepted for publication 19 April 2016

Published 12 August 2016 Volume 2016:5 Pages 35—41

DOI https://doi.org/10.2147/RIP.S87318

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Satyanarayana Lagishetty

Peer reviewer comments 2

Editor who approved publication: Dr Manuel Rodriguez Valle


Soraya T Gaze

Cellular and Molecular Immunology Laboratory, Centro de Pesquisas Rene Rachou – Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil

Abstract: There has been an increase in the number of autoimmune and inflammatory diseases around the world, especially in developing countries. Helminths are masters of inducing an immune response that could potentially overcome those generated by unrelated host diseases. Hence, it is no surprise that there are studies focusing on using helminths to treat some of those diseases. This review focuses on the use of human hookworm Necator americanus as a treatment for some of the autoimmune and inflammatory diseases.

Keywords: Necator americanus, hookworm, autoimmune disease, inflammatory disease, treatment

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