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Existing Data Sources in Clinical Epidemiology: Laboratory Information System Databases in Denmark

Authors Arendt JFH, Hansen AT, Ladefoged SA, Sørensen HT, Pedersen L, Adelborg K

Received 7 January 2020

Accepted for publication 26 March 2020

Published 18 May 2020 Volume 2020:12 Pages 469—475


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Eyal Cohen

Johan Frederik Håkonsen Arendt,1,2 Anette Tarp Hansen,1,3 Søren Andreas Ladefoged,2 Henrik Toft Sørensen,1 Lars Pedersen,1 Kasper Adelborg1,2

1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark; 3Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

Correspondence: Johan Frederik Håkonsen Arendt
Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, Aarhus N 8200, Denmark
Tel +45 87 16 80 63
Fax +45 87 16 72 15

Abstract: Routine biomarker results from hospital laboratory information systems, covering hospitals and general practitioners, in Denmark are available to researchers through access to the regional Clinical Laboratory Information System Research Database at Aarhus University and the nationwide Register of Laboratory Results for Research. This review describes these two data sources. The laboratory databases have different geographical and temporal coverage. They both include individual-level biomarker results that are electronically transferred from laboratory information systems. The biomarker results can be linked to all other Danish registries at the individual level, using the unique identifier, the CPR number. The databases include variables such as the CPR number, date and time (hour and minute) of sampling, NPU code, and name of the biomarker, identification code for the laboratory and the requisitioner, the test result with the corresponding unit, and the lower and upper reference limits. Access to the two databases differs since they are hosted by two different institutions. Data cannot be transferred outside Denmark, and direct access is provided only to Danish institutions. It is concluded that access to data on routine biomarkers expands the detailed biological and clinical information available on patients in the Danish healthcare system. The full potential is enabled through linkage to other Danish healthcare registries.

Keywords: biomarkers, database, data resource, laboratory information systems

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