Menu
Back to Journals » Drug Design, Development and Therapy » Volume 13
Evaluation of the effect of long-term use of antidepressants in the SSRI group on bone density with dental volumetric tomography
Authors Agacayak KS, Guler R, Ilyasov B
Received 23 May 2019
Accepted for publication 26 August 2019
Published 3 October 2019 Volume 2019:13 Pages 3477—3484
DOI https://doi.org/10.2147/DDDT.S216822
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr Anastasios Lymperopoulos
Kamil Serkan Agacayak,1 Rıdvan Guler,1 Bekir Ilyasov2
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University, Diyarbakır, Turkey; 2Private Dental Clinic, Diyarbakır, Turkey
Correspondence: Kamil Serkan Agacayak
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University, Diyarbakir 21280, Turkey
Tel +90 412 241 1017
Email serkanagacayak@gmail.com
Aim: The present study aims to employ dental volumetric tomography to examine bone mineral density among men that used antidepressants in the SSRI group for a long time.
Method: The present study was conducted through the utilisation of data related to patients that presented to the Faculty of Dentistry of Dicle University and had a dental volumetric tomography (DVT) scan for any reason. The patients were divided into 2 groups based on the use of antidepressants: Group 1 included 68 patients as the control group, and Group 2 consisted of 68 patients that used antidepressants. Radiomorphometric measurements were performed on DVT data: DVT-Mandibular Index (DVT-MI), DVT-Cortical Index (DVT-CI), Hounsfıeld Unit (HU) CORTICAL, and HU SPONGIOSIS values were calculated.
Results: The group of patients that used antidepressants exhibited a significant increase in DVT CI and a significant decrease in HU CORTICAL, HU SPONGIOSIS and DVT MI values. These findings were suggestive of osteoporosis.
Conclusion: Long-term use of antidepressants should be taken into consideration as a risk factor for osteoporosis in men.
Keywords: antidepressant, bone density, dental tomography
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.
By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.