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Evaluation of the effect of long-term use of antidepressants in the SSRI group on bone density with dental volumetric tomography

Authors Agacayak KS, Guler R, Ilyasov B

Received 23 May 2019

Accepted for publication 26 August 2019

Published 3 October 2019 Volume 2019:13 Pages 3477—3484

DOI https://doi.org/10.2147/DDDT.S216822

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Anastasios Lymperopoulos


Kamil Serkan Agacayak,1 Rıdvan Guler,1 Bekir Ilyasov2

1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University, Diyarbakır, Turkey; 2Private Dental Clinic, Diyarbakır, Turkey

Correspondence: Kamil Serkan Agacayak
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Dicle University, Diyarbakir 21280, Turkey
Tel +90 412 241 1017
Email serkanagacayak@gmail.com

Aim: The present study aims to employ dental volumetric tomography to examine bone mineral density among men that used antidepressants in the SSRI group for a long time.
Method: The present study was conducted through the utilisation of data related to patients that presented to the Faculty of Dentistry of Dicle University and had a dental volumetric tomography (DVT) scan for any reason. The patients were divided into 2 groups based on the use of antidepressants: Group 1 included 68 patients as the control group, and Group 2 consisted of 68 patients that used antidepressants. Radiomorphometric measurements were performed on DVT data: DVT-Mandibular Index (DVT-MI), DVT-Cortical Index (DVT-CI), Hounsfıeld Unit (HU) CORTICAL, and HU SPONGIOSIS values were calculated.
Results: The group of patients that used antidepressants exhibited a significant increase in DVT CI and a significant decrease in HU CORTICAL, HU SPONGIOSIS and DVT MI values. These findings were suggestive of osteoporosis.
Conclusion: Long-term use of antidepressants should be taken into consideration as a risk factor for osteoporosis in men.

Keywords: antidepressant, bone density, dental tomography

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