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Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study

Authors Kalapanida D, Zagouri F, Gazouli M, Tsiakou A, Zografos E, Dimitrakakis C, Marinopoulos S, Giannos A, Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA

Received 2 October 2018

Accepted for publication 29 November 2018

Published 28 May 2019 Volume 2019:12 Pages 4195—4202

DOI https://doi.org/10.2147/OTT.S189329

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Federico Perche


Despoina Kalapanida,1 Flora Zagouri,1 Maria Gazouli,2 Andriani Tsiakou,3 Eleni Zografos,2 Constantine Dimitrakakis,4 Spyridon Marinopoulos,4 Aris Giannos,4 Theodoros N Sergentanis,1 Efstathios Kastritis,1 Evangelos Terpos,1 Meletios-Athanassios Dimopoulos1

1Department of Clinical Therapeutic, Alexandra Hospital, Medical School, University of Athens, Athens, Greece; 2Department of Basic Medical Sciences, Laboratory of Biology, University of Athens School of Medicine and Laboratory of Cell and Gene Therapy, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; 3First Department of Dermatology, Syggros Hospital, University of Athens School of Medicine, Athens, Greece; 4Department of Obstetrics and Gynaecology, Alexandra Hospital, Medical School, University of Athens, Athens, Greece

Aim: The purpose of this study is to evaluate the role of MET T1010I and MET rs40239 as potential risk factor and/or prognostic markers in patients with triple-negative breast cancer (TNBC).
Methods: 114 samples of DNA from paraffin-embedded breast normal tissues of patients with TNBC and 124 samples of healthy controls were collected and analyzed for MET T1010I and MET rs40239 polymorphisms.
Results: MET T1010I CT genotype was associated with increased risk of TNBC in both univariate and multivariate analysis. The status of rs40239 was not associated with a higher risk for TNBC at either the univariate or the multivariate analysis. None of the examined polymorphisms was associated with overall survival at the univariate or multivariate Cox regression analysis (adjusted HR=1.35, 95% CI: 0.31–5.97 for MET T1010I CT/TT vs CC; adjusted HR=1.78, 95% CI: 0.73–4.35 for rs40239 AG/GG vs AA).
Conclusion: Our case–control study suggests that MET T1010I seems to be a risk factor for TNBC in the Caucasian Greek population, in contrast with MET rs40239, where no correlation was found.

Keywords: SNPS, MET T1010I, MET rs40239, triple-negative breast cancer, biomarker

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