Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 13

Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease

Authors Aras YG, Aydemir Y, Güngen BD, Güngen AC

Received 13 December 2017

Accepted for publication 3 April 2018

Published 7 June 2018 Volume 2018:13 Pages 1857—1862

DOI https://doi.org/10.2147/COPD.S159738

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Yeşim Güzey Aras,1 Yusuf Aydemir,2 Belma Doğan Güngen,3 Adil Can Güngen4

1Department of Neurology, Research and Training Hospital, Sakarya University, 2Department of Pulmonology, Sakarya University, Adapazarı, 3Department of Neurology, Istinye University, 4Department of Pulmonology, Istinye University, Istanbul, Turkey

Background:
The aim of the study was to investigate the frequency and characteristics of peripheral nervous system (PNS) and central nervous system (CNS) involvement in COPD.
Methods: The study included 41 COPD patients and 41 healthy volunteers. Electrophysiological studies were carried out: electromyography (EMG) and visual evoked potentials (VEPs). The median nerve, ulnar nerve, common peroneal nerve, and tibial nerve were evaluated for latency, amplitude, and conduction velocity.
Results: The mean age of patients with COPD was 61.8 years and disease duration 10.3 years. There was no difference between patient and control groups in terms of age, BMI, smoking status, or biochemical parameters. Upon VEP examination, latencies were significantly prolonged and amplitudes shortened in the patient group compared to the control group. In EMG measurements, conduction velocity and amplitudes in all nerves were low in the patient group. Similarly, latencies in all nerves were higher in patients with COPD.
Conclusion: Central and peripheral nervous system involvement could develop in patients with moderate–severe COPD, and these patients should be monitored for neuropathic changes in combination with neurological examination.

Keywords: chronic obstructive pulmonary disease, visual evoked potentials, electromyography, peripheral neuropathy, electrophysiological study

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]