Back to Journals » Neuropsychiatric Disease and Treatment » Volume 12

Evaluation and follow-up of cognitive functions in patients with minor stroke and transient ischemic attack

Authors Deniz C, Celik Y, Ozdemir Gultekin T, Eryigit Baran G, Deniz C, Asil T

Received 10 December 2015

Accepted for publication 22 March 2016

Published 16 August 2016 Volume 2016:12 Pages 2039—2048

DOI https://doi.org/10.2147/NDT.S102193

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Çiğdem Deniz,1 Yahya Çelik,2 Tuğçe Özdemir Gültekin,1 Gozde Eryiğit Baran,1 Çağla Deniz,3 Talip Asil1

1Department of Neurology, Faculty of Medicine, Bezmialem Vakif University, İstanbul, 2Department of Neurology, Faculty of Medicine, Trakya University, Edirne, 3Department of Neurology, Avrupa Hospital, Adana, Turkey

Background and purpose:
We aimed to examine the incidence of cognitive impairment among patients with stroke, the associated risk factors, progression of the cognitive impairment, and the association between the localization of the lesion(s) as detected by magnetic resonance imaging and the affected areas of cognitive function.
Methods: A total of 40 patients over 18 years of age enduring a transient ischemic stroke or minor stroke within the past 3 months who had a minimum life expectancy of 1 year were included in this study. Same number, age-, and sex-matched individuals were included as controls. Patients were inquired on the presence of risk factors for stroke. A series of neuropsychological test batteries were administered in patient and control subjects for assessing cognitive functions. These tests were readministered at 6 and 12 months of follow-up to assess the progression of cognitive functions.
Results: In this study among the patients with stroke, a significant impairment was seen in multiple cognitive functional tests following ischemic stroke as compared to control groups. The most common risk factors for stroke included hypertension (72.5%), hyperlipidemia, and cigarette smoking. The number of cognitive domains with an impairment was highest (in four cognitive tests) among those with coronary artery disease and atrial fibrillation, followed by those who had a >50% stenosis in Doppler (three cognitive tests). These findings suggest that the frequency of risk factors associated with stroke does not correlate with the frequency of risk factors associated with cognitive dysfunction. The stroke localizations were classified among the patients with stroke and reviewed in accordance with cognitive impairment.
Conclusion: Neuropsychological tests, clinical findings, and imaging studies should be used to document the poststroke cognitive dysfunction.

Keywords: dementia, vascular dementia, cognitive impairment, neuropsychological assessment, vascular risk factors

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]