Evaluating the Characteristics, Reporting and Methodological Quality of Systematic Reviews of Acupuncture for Low Back Pain by Using the Veritas Plot
Authors Huang F, Qiu M, Zhao S, Dai L, Xu Y, Yang Y, Lu L, Guo R, Tian Q, Fan Z, Wu S
Received 20 March 2020
Accepted for publication 6 July 2020
Published 19 October 2020 Volume 2020:13 Pages 2633—2652
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Michael A Überall
Fan Huang,1,* Mingwang Qiu,2,* Siyi Zhao,1,* Lin Dai,2 Yanpeng Xu,2 Yunying Yang,2 Liming Lu,2 Rusong Guo,1,3 Qiang Tian,1,3 Zhiyong Fan,1,3 Shan Wu1,3
1The Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, People’s Republic of China; 2Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, People’s Republic of China; 3Guangdong Province Hospital of Chinese Medicine, Guangzhou, Guangdong, 510120, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhiyong Fan; Shan Wu Guangdong Province Hospital of Chinese Medicine, Guangzhou, Guangdong, 510120, People’s Republic of China
; Guangdong Province Hospital of Chinese Medicine, Guangzhou 510120, Guangdong, People’s Republic of China Tel +86 188 9863 2932
Email fzystr[email protected]; [email protected]
Objective: To evaluate systematic reviews (SRs) of acupuncture for low back pain (LBP) in terms of characteristics, reporting and methodological quality using a Veritas plot and to explore factors that may be associated with methodological quality and reporting quality.
Study Design and Setting: We searched 8 electronic bibliographic databases to find all SRs, and we evaluated the SRs’ quality in 6 dimensions, including publication year, design type, homogeneity, risk of publication bias, methodological quality by Assessment of Multiple Systematic Reviews (AMSTAR) 2 and reporting quality by Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Excel 2010 and Adobe Illustrator CC were used to draw and optimize Veritas plots. Exploratory analysis was done using SPSS software version 23.0 to explore factors related to AMSTAR-2 and PRISMA scores. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) evidence quality evaluation tool was used to grade all the outcome indicators in the included literature.
Results: We included 19 SRs in the analysis. Literature quality rank scores ranged from 9.67 to 17.00, with an average score of 13.18 ± 2.35. The average score of AMSTAR-2 was 7.47, and the average score of PRISMA was 18.47. Overall, the main issues were research strategies, inclusion and exclusion criteria, publication bias, and registration in PROSPERO. The results of exploratory analysis showed that duplication of literature selected and appropriate tools to assess the risk of bias were related to the AMSTAR-2 score, and the summary of evidence was related to the PRISMA score. The GRADE quality evaluation results showed mainly low quality.
Conclusion: The quality of SRs on acupuncture for low back pain should be improved, mainly by strengthening the methodological quality and reporting quality. The Veritas plot is an effective graphical evaluation method that is worth popularizing.
Keywords: reporting quality, methodological quality, AMSTAR-2, low back pain, PRISMA, systematic review
As a common and disabling symptom, low back pain (LBP) affected approximately 7.3% of people around the world in 2015.1,2 In the United States, the increase in personal and public health-care costs from 1996 to 2013 indicated an estimated spending of $87.6 billion on the management of lower back and neck pain, the third and fourth highest health-care costs in the disease category.3 Guidelines recommend using medication, imaging, and surgery prudently and suggest that clinicians should consider nonsteroidal anti-inflammatory drugs as first-line therapy.4 However, long-term use of nonsteroid anti-inflammatory drugs may cause gastritis, and high-dose aspirin use may cause tinnitus.5 Therefore, greater emphasis is now placed on education and self-care, physical and psychological therapies, and some forms of complementary medicine.6
In recent years, an increasing number of complementary and alternative therapies have been developed in clinical practice, among which acupuncture plays an important role.7 As a safe and acceptable form of acute analgesia, acupuncture can relieve the symptoms of LBP.8–10 The analgesic mechanism of acupuncture is to stimulate sensory nerve endings, leading to the release of endogenous opioid hormones and other nonopioids in the brain and spinal cord,11–13 which could block the transmission of nerve impulses and thereby relieve pain.14 In the American College of Physicians guideline, six related SRs and RCTs about acupuncture were included on noninvasive treatments for LBP, the oldest of which was published in 2002.15 The guideline still has some limitations because it has not systematically evaluated the SRs of acupuncture for LBP. Therefore, a scientific quality assessment of SRs is necessary to overcome the limitations of the guideline and to facilitate decision-making by clinicians. First used as an evidence-synthesis graphical tool in meta-analysis of cardiac surgery,16 Veritas plots are used to describe multiattribute data and to identify and interpret variability in meta-analyses,17 as well as to assess the key factors of meta-analysis quality such as heterogeneity, study design and publication bias. In addition to Veritas plots, we used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach to assess the quality of evidence from the main findings.18 As a comprehensive graphical tool, Veritas plots could help researchers draw conclusions more intuitively from systematic reviews, so that decision-makers can more easily appraise the quality of meta-analyses, helping them apply high-quality evidence about acupuncture for LBP. Hence, this overview could provide a reference for evidence-based medical research on acupuncture for LBP.
Study Design of Eligible Studies
This study evaluated the SRs of acupuncture for LBP in six dimensions, and the study protocol has been registered on the PROSPERO platform; the registration number is CRD42019122610 (https://www.crd.york.ac.uk/PROSPERO/, CRD).
We searched 8 electronic bibliographic databases: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Wanfang Data Knowledge Service Platform and Chinese Technical Periodicals (VIP) Database from inception to May 19th, 2019. The search strategy included only terms relating to or describing the intervention, and MeSH and free text terms were used to identify relevant literature. The search terms (acupuncture OR electro-Acupuncture OR electroacupuncture OR abdominal acupuncture OR auricular acupuncture OR scalp-acupuncture OR acupuncture treatment OR acupuncture points OR ear acupuncture OR abdominal acupuncture OR needle OR dry needle OR meridian acupoint OR jingluo OR zhenjiu OR zhenci OR dianzhen) AND (low back pain OR back pain OR lumbar near pain OR dorsalgia OR backache OR back disorder OR sciatica OR lumbago OR back disorder OR low discomfort OR lower back pain) AND (Meta-analysis OR systematic review) were used in English-language databases, while “jingluo”, “zhenjiu ”, “zhenci”, “dianzhen”, “xiayaotong”, “yaotong”, “beitong”, “xitongpingjia”, and “meta” were used in Chinese-language databases. The search details are presented in Additional Information.
Inclusion and Exclusion Criteria
The inclusion criteria were the following: (1) population: patients with LBP; (2) interventions: acupuncture was evaluated as monotherapy or part of combination therapy, which included all kinds of acupuncture, regardless of its frequency or duration; (3) comparisons: pharmacotherapies, surgery, manipulation, placebo, or a different acupuncture treatment were considered; and (4) study design: SR. Studies meeting the following were excluded: (1) letters, editorials and expert opinions, case reports, abstracts only, and conference proceedings; (2) articles with no extractable data available; (3) articles published not in English or Chinese; and (4) articles unrelated to acupuncture or low back pain. Moreover, if the same author and/or institution was reported in more than one study, only the most recent study or largest population was included.
Data Extraction and Management
We used EndNote X9 software (https://endnote.com/) for screening, to exclude duplicate studies, and to further screen after reading the information. Two researchers (F. H. and M. W. Q.) independently extracted data using a Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) flowchart19 and Microsoft Excel 2010 (http://office.microsoft.com/zh-cn/). The following were extracted from the included studies: author, country, condition, participants, interventions, methodological quality assessment tool and main conclusions. In case of disagreements, a third author (S. Y. Z.) participated in consensus conferences.
In order to analyze the factors related to Assessment of Multiple Systematic Reviews 2 (AMSTAR-2) and PRISMA scores and their effect sizes, we used multiple linear and ordinal regression analyses to model AMSTAR-2 and PRISMA scores as dependent variables. Only variables with p ≤ 0.10 on univariate analysis were included in the multivariate regression model to identify significant variables (p ≤ 0.05). Linear and ordinal regression analysis was performed using SPSS software version 23.0.
Two authors (F. H. and M. W. Q.) independently evaluated the methodological quality of the included studies using AMSTAR-2 and PRISMA. The AMSTAR-220 tool is an improved 16-item instrument that assesses key attributes of a well-conducted meta-analysis. Aspects such as prior design, literature search, data extraction, and data analysis were assessed by AMSTAR-2. We also used the PRISMA21 statement, a checklist with 27 items and 1 flowchart (4 stages), which contains the necessary entries for a transparent report on SRs to assess the risk of bias.
Veritas scores were determined for publication year, type of study, AMSTAR-2 score, PRISMA score, heterogeneity, and publication bias. Since disease and acupuncture techniques change over time, the year of publication is also an important factor in the study of heterogeneity.22 AMSTAR-2, updated in 2017, provides readers with a better assessment of research.23 Additionally, the PRISMA statement provides a standardized framework and allows authors to make full reports on SRs and assesses their quality.21 The heterogeneity of the study was included because it has a significant impact on the results of meta-analysis.24 Some studies are not published in index journals, and the negative results of some studies are not disclosed, so it is necessary to assess publication bias.25
The AMSTAR-2 scale comprises 16 items that are answered as “Yes” (item fully addressed), “No” (item not addressed), or “Partially satisfied” (item not fully addressed), resulting in scores from 0 to 16.20 Each item of the PRISMA scale is standardized and has a score of 1 for correctly used, 0.5 for insufficiently used, and 0 for unused or misused, with a full score of 27.21 The rank number of the remaining items is converted according to the medical statistics grade data processing method.26 In terms of the year of publication, the latest published article ranked the highest. When randomization is performed using mathematical techniques, the trial is characterized as a randomized controlled trial (RCT), such as using a random numbers table to assign patients to testing or controlled treatment. However, trials employing allocation methods such as coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudorandom processes are simply designated as controlled clinical trials (CCT). Among the included studies, RCTs are high-quality designs, while CCTs are low-quality. The heterogeneity score is the average of the heterogeneity score for clinical outcomes, which is assessed using the chi-square test and I2 statistic. More than half of the indexes in the literature on SRs showed that when p > 0.10, 0% ≤ I2 < 50%, the homogeneity indicates no heterogeneity, and the score is 3 points; 0.10 ≥ p ≥ 0.05, 50% ≤ I2 ≤ 75% is regarded as slightly significant heterogeneity with a score of 2 points, and 0.05 > p, I2 > 75% is considered significant heterogeneity with a score 1 point.24 If the publication bias is ignored, the risk of publication bias would be high.25
The scoring system was as> follows: in each project, the worst study gets a minimum score of 1 point, the second-to-last study gets 2 points, and so on. The best study is given the highest score n, where n= the number of studies. If there are two studies with the same score n, then the next included study will get n-2 points.27 The Veritas score was used as the final summary data. The score of each study was the average score in the six dimensions of quality.
The Drawing and Optimization of Veritas Plots
We used Excel 2010 and Adobe Illustrator CC (https://adobe-illustrator.en.softonic.com/) to draw and optimize the Veritas plots. The rank number of the above evaluation items in the overall literature was the value of each study in the coordinates of the Veritas plots. When drawing and optimizing the Veritas plots, Excel 2010 was used to generate the image, which was saved in a separate sheet. Then, we opened the image, exported the vector, calculated the diameter, created a polar coordinate grid, drew petals and did other optimization work in Adobe Illustrator CC to make the Veritas plots.
Selection of Studies
The initial search detected 701 related publications, and 272 duplicated records were excluded by EndNote X9. After reading the titles and abstracts, 395 records were excluded from the preliminary screening, and after further screening, 15 studies were excluded. A total of 19 SRs were included for multivariate evaluation by Veritas plot.28–46 The literature retrieval and screening process is shown in Figure 1.
Figure 1 The literature retrieval and screening process.
The years of publication of the included studies ranged from 1998 to 2018. There were 6 SRs28,31,37,39,43,44 on unrestricted types of LBP, 1 SR30 on acute LBP, 5 SRs32–35,40 on chronic LBP, 2 SRs36,38 on nonspecific LBP, 4 SRs29,41,42,45 on chronic nonspecific LBP, and 1 SR46 on acute, subacute or chronic nonspecific LBP.
As for the risk-of-bias tools, 10 SRs28–30,32,36,37,42,44–46 used Cochrane alone, 1 SR31 used the Jadad scale alone, 1 SR38 used the van Tulder scale alone, 1 SR39 used the 2003 CBRGC (Cochrane Back Review Group Criteria) and the Jadad scale, and 1 SR40 used CBRGC alone. No tools for risk assessment were used in the other 5 SRs.33–35,41,43 Fourteen SRs38 provided quality assessment, but every RCT was of low quality.
In the experimental group, 12 SRs30–36,38–42 used acupuncture alone as an intervention, and the remaining 7 SRs28,29,37,43–46 used acupuncture combined with other therapies. In the control group, 6 SRs29,31,33,34,36,37 were treated with placebo or sham acupuncture alone as interventions, and 13 SRs28,30,32,35,38–46 were treated with placebo or sham acupuncture combined with other therapies as interventions. The basic information included in SRs is shown in Table 1.
Table 1 Descriptive Characteristics of the Included Systematic Reviews
The results of the evaluation entries are shown in Table 2.
Table 2 Multivariate Evaluation and Rank Number in 6 Dimensions of the Included Literature
Year of Publication
When the research literature on clinical issues is relatively new and involves a larger scope and time span, it is more meaningful to provide clinical guidance.46 In this study, the latest year of publication was 2018,33,45 and the earliest was 1998.31 Each of the years 2005,39,46 2007,37 2009,36 and 201644 contained 1 article. Each of the years 2008,38,40,43 2012,28,34,41 and 201330,32,42 contained 3 articles. Two articles were published in 2010.29,35
Types of Included Studies
Systematic reviews and meta-analyses based on high-quality randomized controlled trials are at the top of the pyramid of evidence recommendations, and the main source of evidence is high-quality randomized controlled trials.47,48 The 18 reports of RCTs29–46 and only 1 CCT28 included in this study reduced the risk of bias.
Of the 19 RCT articles, the highest score on AMSTAR-2 was 11.5,42,45 the lowest was 3.5,31,41 and the average score was 7.47. One article31 did not carry out a comprehensive literature search strategy, and only 1 article29 considered the literature completely, the others partially. Ten articles31,33,35–37,40–43,46 only provided the list of included literature but did not provide the list of excluded literature, which was unfavorable for the judgment of literature quality. Sixteen articles29,30,33–46 did not indicate whether there was publication bias. Ten articles31,32,34–36,40–42,44,46 did not describe conflicts of interest. The details of AMSTAR-2 of included studies are presented in Additional Table 1.
The average PRISMA score included in our study was 18.47, with a maximum score of 25.528 and a minimum score of 14.33,35 All of the articles consisted of title, standard abstract, the current known theoretical basis of the study, detailed inclusion criteria, the number of preliminary screening articles, characteristics of the study, limitations and conclusions. Only 5 studies28,30,39,41,45 detailed the search strategy. None of the 1928–46 SRs included was registered on the PROSPERO platform. The details of AMSTAR-2 of included studies are presented in Additional Table 2.
As defined above, among the 19 articles, homogeneity was high except for the low heterogeneity of Rubinstein et al,29 Ernst et al,31 Vickers et al,33,34 Trigkilidas et al,35 Machado et al,36 Yuan et al,38 Manheimer et al,39 Ammendolia et al,40 Hutchinson et al,41 Johnston et al32 and Furlan et al.46 The details of Heterogeneity score of included studies are presented in Additional Table 3.
Veritas Plot Evaluation
Based on the evaluation of Veritas plots and the average rank numbers of all the studies, it was found that the study with the highest Veritas score was by Liang et al,44 with 17.00 points, while the lowest Veritas score was given to Ernst et al31 and Keller et al,37 with 9.67 points. There were 7 studies29,30,32,34,42,44,45 with Veritas scores ≥13.18 points, which was the average score. The Veritas plots are shown in Figure 2.
Figure 2 The Veritas plots.
Exploratory Analysis: Factors Associated with Methodological Quality and Reporting Quality
In univariate analysis, duplication of literature selected, the exclusion list and reasons for exclusion, appropriate tools to assess the risk of bias, appropriate statistical methods to combine results, assessment of the impact of bias risk on results, and reasonable analysis of bias risk were associated with an increase in AMSTAR-2 score (p≤0.10). After the above six variables were included in the multivariate linear regression model, the results showed that duplication of literature selected and appropriate tools to assess the risk of bias were still independent variables significantly affecting AMSTAR-2 score (p≤0.05). It was found that appropriate tools to assess the risk of bias had the largest impact on AMSTAR-2 score, reaching 2.262 (95% CI, 0.941~3.582; p = 0.003). (Table 3)
Table 3 Multivariate Linear Regression Analysis for Variables Associated with Better AMSTAR2 Score (n = 19)
In univariate analysis, the title, eligibility criteria, retrieval, existing bias in a single study, research bias, the results of a single study, inter-research bias, and summary of evidence were associated with an increase in PRISMA score (p≤0.10). The multivariate linear regression model showed that the summary of evidence was still an independent and significant variable affecting PRISMA score (p≤0.05). Specifically, it was obvious that the summary of evidence had the largest impact on PRISMA score, reaching 6.993 (95% CI, 1.433~12.553; p <0.05) (Table 4).
Table 4 Multivariate Linear Regression Analysis for Variables Associated with Better PRISMA Score (n = 19)
GRADE Grading of Evidence Quality
A total of 52 outcome indicators were included in the 19 SRs. The GRADE was used to evaluate the evidence intensity reports of outcome indicators of the SRs (Table 5). The results showed that a total of 33 outcome indicators were of low quality, 10 outcome indicators were of very low quality, 8 outcome indicators were of medium quality, and only 1 outcome indicator was of high quality.
Table 5 Quality of Evidence of the Included Systematic Reviews
With the help of the Veritas scores, we ultimately found that the mean Veritas plot scores of lack of publication year, type of study, AMSTAR-2, PRISMA, heterogeneity, and publication bias were 10.58, 18.05, 10.05, 10.42, 13.53, and 16.47, respectively. The study of Liang et al44 performed well in the year of publication, type of study, AMSTAR-2 score, PRISMA score and publication bias, earning it the highest Veritas score of 17 points. After close therewith is study of Lee30 and Xiang,45 with 16.67 points, respectively. They only have few difference in Year AMSTAR 2 score and homogeneity. As for AMSTAR-2, the outcomes of the review method, the assessment of the potential impact of risk of bias in individual studies on the results, the list of excluded studies, the funding sources, and the conflicts of interest were insufficient. In addition, in the case of PRISMA, the lack of a literature screening process, the lack of PROSPERO registration, and the absence of other analytical methods, such as sensitivity analysis and subgroup analysis, among others, were the main problems. Through observation of Veritas plots, we found that three principal problems of SRs were lack of publication bias, poor quality of reporting and methodology. The absence of publication bias assessment was an important problem in the SRs. Some SRs29,30,33–36 did not assess publication bias, and the absence of publication bias assessment may seriously affect the validity of the conclusions derived from the meta-analysis.34 Therefore, the clinical value of the results should be carefully considered. Moreover, the selection of acupuncture points and the treatment duration of each RCT included in the SRs may be different due to the specific situation of every patient. The skill level of the acupuncturists is a common problem in acupuncture therapy. Hence, subgroup analysis should be carried out, and acupoint selection should be explained, but our overview found that most of the SRs about this aspect were lacking.
By univariate analysis and multivariate linear regression, we found that duplication of literature selected and appropriate tools to assess the risk of bias were related to the AMSTAR-2 score, and summary of evidence was related to the PRISMA score. Best practice requires two authors to determine the eligibility of studies for inclusion in systematic reviews.49 Duplication of literature selected could ensure that as many qualified studies as possible are included, preventing omissions. The authors should choose the appropriate evaluation tool to evaluate the potential risk of bias in RCT intervention studies, which could objectively and correctly evaluate the risk of bias and analyze it to obtain more objective results.23 In the Discussion section, the authors should discuss the strength of the evidence of the relevant indicators in the study, because summary of evidence will lead different people to make different decisions.50 We used GRADE as an evidence quality evaluation tool.51 Only 1.9% high-quality evidence, 15.3% medium-quality evidence, and 82.6% low- to very low-quality evidence were found. Table 5 also shows that the factors leading to the degradation of evidence quality are mainly a lack of description of the randomization method as well as allocation and concealment methods.
SRs of evidence-based medicine are the top of the evidence tower and the best evidence to guide clinical practice.52 A high methodological and reporting quality of a SR means that the study design and implementation specifications are rigorous, and the results are repeatable, accurate, and clinically recommended.53 In our study, a Veritas plot was used to conduct a multidimensional analysis on the relevant indicators of SRs for acupuncture of low back pain. The overall quality of SRs and the data difference between a given SR and the average score were found, yielding intuitive and accurate evidence, demonstrating their advantages and disadvantages, and providing reference for clinical application. During the search process, we found that one article published in 2018 had a similar methodology as this study.54 Our study had more perspectives and higher accuracy because items such as the publication year, type of study, heterogeneity, and publication bias were added, and the AMSTAR was updated to AMSTAR-2.
This overview also has some limitations. One limitation is that due to language barriers, we only searched for manuscripts published in Chinese and English journals. Moreover, we observed the quality of the articles directly by the Veritas plot, a simple two-dimensional tool, which provides a visual mode of observation without much description. However, due to its subjectivity, authors in other fields may dispute the emphasis we have placed on the attributes in our Veritas plot. Of equal importance is the fact that it is difficult to compare the comprehensive strength between the objects when there are many objects involved in the evaluation. This tool cannot compare the quality of studies from different clinical areas at present.
In view of the above shortcomings, future appraisers who use meta-analyses need to assess the validity, reliability and perceived utility of the Veritas plot to quickly obtain the rankings for comprehensive evaluation and ensure its fairness and accuracy.
In conclusion, our study indicates that the methodology and reporting quality of SRs for acupuncture treatment of LBP still need to be improved. Future studies should make full use of the AMSTAR-2 tool and PRISMA statement to publish articles on this topic. The Veritas plot is an intuitive visualization tool for observing the quality of articles and is worthy of clinical application and promotion.
- This study evaluated the overall quality of SRs in 6 dimensions and explored factors that may affect their quality.
- The quality of SRs for acupuncture treatment of low back pain was low, mainly manifested in research strategies, inclusion and exclusion criteria, publication bias, and registration in PROSPERO.
- GRADE quality evaluation results showed mainly low quality.
- The Veritas diagram is an intuitive visualization tool for observing the quality of articles, which is worthy of clinical application and promotion.
SR, systematic review; LBP, low back pain; AMSTAR 2, Assessment of Multiple Systematic Reviews 2; PRISMA, Preferred Reporting Items of Systematic Reviews and Meta-Analyses; RCT, randomized controlled trial; GRADE, Grading of Recommendations, Assessment, Development and Evaluation.
We would like to thank Associate Professor Liming Lu (LL) for his help with the methodology of our study, Designer Xiaotao Hu for his help in making figures, and Chuyu Huang for her help in English writing and polishing.
All authors made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data, drafting the manuscript, revising the manuscript critically, read and approve the final draft of the manuscript for submission, gave final approval of the manuscript version to be published and agreed to be accountable for every step of the work. Fan Huang, Mingwang Qiu, Siyi Zhao are co-first authors (Fan Huang, Mingwang Qiu and Siyi Zhao contributed equally to this work).
This work was supported by (1) National Natural Science Foundation of China (Grant No. 81874511); (2) Guangdong Provincial Department of Finance Project [Grant (2016) No. 387]; (3) Innovation and Entrepreneurship Program for College Students of Guangzhou University of Chinese Medicine (Grant No. 201910572001; 201910572245; 202010572048; 202010572176).
There are no financial or other interests with regard to the submitted article that might be construed as a conflict of interest. The authors report no conflicts of interest for this work.
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