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Ethics of conducting the study "Oral 24% sucrose associated with nonnutritive sucking for pain control in healthy term newborns receiving venipuncture beyond the first week of life" [Letter]

Authors Harrison D, Bueno M

Received 3 February 2019

Accepted for publication 4 May 2019

Published 20 June 2019 Volume 2019:12 Pages 1913—1914


Checked for plagiarism Yes

Editor who approved publication: Dr E Alfonso Romero-Sandoval

Denise Harrison,1 Mariana Bueno2

1The University of Ottawa and Children’s Hospital of Eastern Ontario, Ottawa, Canada; 2The Hospital for Sick Children, Toronto, Canada

We refer to the pilot study by De Bernardo et al,1 in which 66 healthy infants were randomized to 24% sucrose or 10% glucose during venipuncture. Findings were 24% sucrose statistically significantly reduced pain compared to 10% glucose. This is not surprising as the efficacy of sweet tasting solutions in reducing pain in newborn infants has been known since the early 2000s,2 and less concentrated solutions, including the 10% glucose used in this study had already been shown to be ineffective. Therefore, this trial, which studied an already known effective
intervention compared to an already known ineffective intervention, does not comply with the principle of equipoise.2,3

View the original paper by De Bernardo and colleagues

A Response to Letter has been published for this article 

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