Back to Journals » Journal of Pain Research » Volume 12

Ethics of conducting the study "Oral 24% sucrose associated with nonnutritive sucking for pain control in healthy term newborns receiving venipuncture beyond the first week of life" [Letter]

Authors Harrison D, Bueno M

Received 3 February 2019

Accepted for publication 4 May 2019

Published 20 June 2019 Volume 2019:12 Pages 1913—1914

DOI https://doi.org/10.2147/JPR.S203526

Checked for plagiarism Yes

Editor who approved publication: Dr E Alfonso Romero-Sandoval


Denise Harrison,1 Mariana Bueno2

1The University of Ottawa and Children’s Hospital of Eastern Ontario, Ottawa, Canada; 2The Hospital for Sick Children, Toronto, Canada

We refer to the pilot study by De Bernardo et al,1 in which 66 healthy infants were randomized to 24% sucrose or 10% glucose during venipuncture. Findings were 24% sucrose statistically significantly reduced pain compared to 10% glucose. This is not surprising as the efficacy of sweet tasting solutions in reducing pain in newborn infants has been known since the early 2000s,2 and less concentrated solutions, including the 10% glucose used in this study had already been shown to be ineffective. Therefore, this trial, which studied an already known effective
intervention compared to an already known ineffective intervention, does not comply with the principle of equipoise.2,3

View the original paper by De Bernardo and colleagues

A Response to Letter has been published for this article 

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]