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Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties

Authors Gallelli L

Received 5 March 2019

Accepted for publication 9 July 2019

Published 27 September 2019 Volume 2019:13 Pages 3425—3437

DOI https://doi.org/10.2147/DDDT.S207720

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Qiongyu Guo


Luca Gallelli1,2

1Department of Health Science, School of Medicine, University of Catanzaro, Catanzaro, Italy; 2Operative Unit of Clinical Pharmacology and Pharmacovigilance, Azienda Ospedaliera Mater Domini, Catanzaro, Italy

Correspondence: Luca Gallelli
Operative Unit of Clinical Pharmacology and Pharmacovigilance, Azienda Ospedaliera Mater Domini, Viale Tommaso Campanella 115, Catanzaro 88100, Italy
Tel +39 96 171 2322
Fax +39 96 177 4424
Email gallelli@unicz.it

Abstract: This review discusses historical and recent pharmacological and clinical data on the anti-edematous, anti-inflammatory, and venotonic properties of escin (Reparil®). Escin, the active component of Aesculus hippocastanum, or horse chestnut, is available as orally absorbable dragées and as a transdermal gel. The anti-inflammatory and anti-edematous effects of escin have been studied over many years in pre-clinical models. More recent data confirm the anti-inflammatory properties of escin in reducing vascular permeability in inflamed tissues, thereby inhibiting edema formation. The venotonic effects of escin have been demonstrated primarily by in vitro studies of isolated human saphenous veins. The ability of escin to prevent hypoxia-induced disruption to the normal expression and distribution of platelet endothelial cell-adhesion molecule-1 may help explain its protective effect on blood vessel permeability. Escin oral dragées and transdermal gel have both demonstrated efficacy in blunt trauma injuries and in chronic venous insufficiency. Both oral escin and the transdermal gel are well tolerated.

Keywords: blunt trauma, chronic venous insufficiency, edema, escin, pain, Reparil®

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