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Epidemiology of idiopathic pulmonary fibrosis

Authors Ley B, Collard HR

Received 22 September 2013

Accepted for publication 16 October 2013

Published 25 November 2013 Volume 2013:5(1) Pages 483—492

DOI https://doi.org/10.2147/CLEP.S54815

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Brett Ley, Harold R Collard

Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California, USA

Abstract: Idiopathic pulmonary fibrosis is a chronic fibrotic lung disease of unknown cause that occurs in adults and has a poor prognosis. Its epidemiology has been difficult to study because of its rarity and evolution in diagnostic and coding practices. Though uncommon, it is likely underappreciated both in terms of its occurrence (ie, incidence, prevalence) and public health impact (ie, health care costs and resource utilization). Incidence and mortality appear to be on the rise, and prevalence is expected to increase with the aging population. Potential risk factors include occupational and environmental exposures, tobacco smoking, gastroesophageal reflux, and genetic factors. An accurate understanding of its epidemiology is important, especially as novel therapies are emerging.

Keywords: idiopathic pulmonary fibrosis, epidemiology, incidence, prevalence, mortality, risk factors

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