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Epidemiology and disease burden of tuberculosis in children: a global perspective

Authors Seddon JA, Shingadia D

Received 17 January 2014

Accepted for publication 4 March 2014

Published 18 June 2014 Volume 2014:7 Pages 153—165

DOI https://doi.org/10.2147/IDR.S45090

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

James A Seddon,1 Delane Shingadia2

1Department of Paediatric Infectious Diseases, Imperial College London, London, UK; 2Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, UK

Abstract: Our understanding of the tuberculosis (TB) epidemic in children is incomplete due to challenges in diagnosis and reporting. Children have also been largely excluded from research and advocacy. However, the tide appears to be turning and interest in pediatric TB is increasing. In this article, we explore the epidemiology of childhood TB by first reviewing the natural history of TB in children and the factors that impact on each of the stages from exposure to disease. We then discuss how these factors affect what we see at a country and regional level. Finally, we assess the burden of childhood TB globally.

Keywords: tuberculosis, children, epidemiology, burden, global

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