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Epidemiologic and Clinical Characteristics of 26 Cases of COVID-19 Arising from Patient-to-Patient Transmission in Liaocheng, China

Authors Wang L, Duan Y, Zhang W, Liang J, Xu J, Zhang Y, Wu C, Xu Y, Li H

Received 15 February 2020

Accepted for publication 1 April 2020

Published 9 April 2020 Volume 2020:12 Pages 387—391

DOI https://doi.org/10.2147/CLEP.S249903

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Vera Ehrenstein


Lizhen Wang, 1 Yueting Duan, 1 Wenming Zhang, 2 Juan Liang, 2 Jianxiang Xu, 3 Yongqing Zhang, 3 Changgang Wu, 3 Yangling Xu, 3 Hua Li 2

1Department of Tuberculosis, Liaocheng Infectious Disease Hospital, Liaocheng, Shandong, People’s Republic of China; 2Intensive Care Unit, Liaocheng Infectious Disease Hospital, Liaocheng, Shandong, People’s Republic of China; 3Department of Respiration, Liaocheng Infectious Disease Hospital, Liaocheng, Shandong, People’s Republic of China

Correspondence: Hua Li
Department of Respiration, Liaocheng Infectious Disease Hospital, 45 Jianshe Eastern Road, Dongchang, Liaocheng, Shandong 252000, People’s Republic of China
Email weiyichunguang@163.com

Introduction: Over 40,000 cases of coronavirus (CoV) disease 2019 (COVID-19) have been confirmed in China. The causative agent, 2019 novel CoV (2019-nCoV), has spread rapidly to more than 25 countries worldwide. Human-to-human transmission has accounted for most of the infections outside Wuhan. Most studies to date on COVID-19 have focused on disease etiology and the genomics of 2019-nCoV, with few reports on the epidemiologic and clinical characteristics of infected patients.
Methods: We report early clinical features of 26 patients with confirmed COVID-19 who were admitted to Liaocheng Infectious Disease Hospital in Shandong Province.
Results: The median age of the 26 patients with COVID-19 in this study was 42 years. The most common occupation was retail staff (16 patients, 61.54%), with 11 patients or their family members working at the same supermarket. Only 2 patients had visited Wuhan since December 2019; the other cases of 2019-nCoV infection arose from patient-to-patient transmission. Twelve patients had more than one sign or symptom; however, seven patients had no sign or symptom. The average time from symptom onset to admission was 4.5 days. CT revealed signs of bronchitis in 2 patients and unilateral and bilateral pneumonia in 9 and 15 patients, respectively. The patients received the following treatments: antiviral therapy (100%), Chinese medicine (76.92%), antibiotics (50%), gastric mucosal protection (19.23%), immunotherapy (7.69%), and glucocorticoids (3.85%). Most patients (25/26) required ≥ 1 treatment.
Discussion: In contrast to previous reports, most patients (24/26) had not been in close contact with individuals from Wuhan. Additionally, 11 patients or their family members worked at the same supermarket, suggesting active viral transmission in a location frequented by a large number of people. Close monitoring is essential for preventing the large-scale spread of the virus in such places.

Keywords: coronavirus disease 2019, human-to-human transmission, epidemiologic characteristics, clinical characteristics

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