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Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Authors Muluh TA, Chen Z, Li Y, Xiong K, Jin J, Fu S, Wu J

Received 17 December 2020

Accepted for publication 14 February 2021

Published 25 March 2021 Volume 2021:16 Pages 2389—2404

DOI https://doi.org/10.2147/IJN.S295300

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Mian Wang


Tobias Achu Muluh,1,* Zhuo Chen,1,* Yi Li,1,* Kang Xiong,1 Jing Jin,1 ShaoZhi Fu,1– 3 JingBo Wu1– 3

1Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, People’s Republic of China; 2Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, 646000, Sichuan, People’s Republic of China; 3Department of Oncology, Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan, 646000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: ShaoZhi Fu; JingBo Wu
Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, People’s Republic of China
Tel/Fax +86 8303165696
Email [email protected]; [email protected]

Abstract: Recently, there has been an incredible increase in research about the abnormal growth of cells (neoplasm), focusing on the management, treatment and preventing reoccurrence. It has been understood that the natural defense system, composed of a variety of immune defensive cells, does not just limit its function in eliminating neoplastic cells, but also controls the growth and spread of tumor cells of different kinds to other parts of the body. Cancer immunotherapy, is a cancer treatment plan that educates the body’s defensive system to forestall, control, and eliminate tumor cells. The effectiveness of immunotherapy is achieved, to its highest efficacy, by the use of nanoparticles (NPs) for precise and timely delivery of immunotherapies to specific targeted neoplasms, with less or no harm to the healthy cells. Immunotherapies have been affirmed in clinical trials as a cancer regimen for various types of cancers, the side effects resulting from imprecise and non-targeted conveyance is well managed with the use of nanoparticles. Nonetheless, we will concentrate on enhancing cancer immunotherapy approaches by the use of nanoparticles for the productivity of antitumor immunity. Nanoparticles will be presented and utilized as an objective immunotherapy delivery system for high exactness and are thus a promising methodology for cancer treatment.

Keywords: tumor immunotherapy, immune system, nanoparticles, drug delivery, drug release

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