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Enhanced anti-tumor immunotherapy by silica-coated magnetic nanoparticles conjugated with ovalbumin

Authors Lee SJ, Kim JJ, Kang KY, Paik MJ, Lee G, Yee ST

Received 13 November 2018

Accepted for publication 27 July 2019

Published 16 October 2019 Volume 2019:14 Pages 8235—8249

DOI https://doi.org/10.2147/IJN.S194352

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Anderson Oliveira Lobo


Sung-Ju Lee,1 Jong-Jin Kim,2 Kyung-Yun Kang,3 Man-Jeong Paik,1 Gwang Lee,4 Sung-Tae Yee1

1Department of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of Korea; 2Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea; 3Suncheon Research Center for Natural Medicines, Suncheon, Republic of Korea; 4Department of Physiology and Department of Biomedical Science, Ajou University School of Medicine, Suwon, Republic of Korea

Correspondence: Sung-Tae Yee
Department of Pharmacy, Sunchon National University, 255 Joongang-Ro, Seokhyeon-Dong, Suncheon 549-742, Republic of Korea
Tel +82 61 750 3752
Fax +82 61 750 3708
Email sungtae@sunchon.ac.kr

Background: The effective induction of an antigen-specific T cell immune response through dendritic cell activation is one of the key goals of tumor immunotherapy.
Methods: In this study, efficient antigen-delivery carriers using silica-coated magnetic nanoparticles were designed and, their antigen-specific T cell immune response through dendritic cell activation investigated.
Results: The results showed that the silica-coated magnetic nanoparticles with conjugated ovalbumin enhanced the production of cytokines and antigen uptake in bone marrow-derived dendritic cells. Also, this induced an antigen-specific cytotoxic T lymphocyte (CTL) immune response and activated antigen-specific Th1 cell responses, including IL-2 and IFN-γ production and proliferation. We proved that the immune-stimulatory effects of silica-coated magnetic nanoparticles with conjugated ovalbumin were efficient in inhibiting of tumor growth in EG7-OVA (mouse lymphoma-expressing ovalbumin tumor-bearing mice model).
Conclusion: Therefore, the silica-coated magnetic nanoparticles with conjugated ovalbumin are expected to be useful as efficient anti-cancer immunotherapy agents.

Keywords: antigen-delivery systems, silica-coated magnetic nanoparticles, ovalbumin, EG-7, dendritic cell, CD4+ T cell, CD8+ T cell

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