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Endoscopic Submucosal Dissection of Gastrointestinal Stromal Tumours: A Retrospective Cohort Study

Authors Jiao R, Zhao S, Jiang W, Wei X, Huang G

Received 4 March 2020

Accepted for publication 1 May 2020

Published 29 May 2020 Volume 2020:12 Pages 4055—4061

DOI https://doi.org/10.2147/CMAR.S252459

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Yong Teng


Ruonan Jiao,* Si Zhao,* Wei Jiang, Xin Wei, Guangming Huang

Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Guangming Huang Email hgmnjmu@hotmail.com

Background: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms. Endoscopic submucosal dissection (ESD) has been used to remove submucosal tumours for many years. However, whether ESD can be recommended for the treatment of GISTs is still controversial. Therefore, we evaluated the efficacy and safety of ESD for treating GISTs.
Patients and Methods: We retrospectively analysed 75 GIST patients who underwent ESD in our hospital from January 2016 to December 2018, and the demographic data, clinical presentation of tumours, operative parameters, postoperative complications and length of hospital stay were analysed.
Results: Seventy-five patients successfully underwent en bloc resection, and 74 (98.7%) patients underwent complete resection of the lesions, with an average tumour size of 1.7 cm (range 0.3– 6.0 cm). The median operation time was 84.8 min (range 20– 180 min). Forty-two (56.0%) patients underwent endoscopic purse-string suture with no conversions to an open operation. The median postoperative length of hospitalization was 6.6 days (range 3– 14 days). Out of a total of 75 GIST patients, 48 (64.0%) were considered very low risk, 19 (25.3%) were low risk, 5 (6.7%) were mild risk, and 3 (4.0%) were high risk. The median follow-up was 24.0 months (range 6– 45 months). During hospitalization and follow-up, no complications, recurrence or metastasis occurred.
Conclusion: Based on our study from a medical centre, ESD is a safe and effective method for treating GISTs. However, further studies are needed.

Keywords: endoscopic submucosal dissection, gastrointestinal stromal tumour, prognosis
 

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