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Endogenous cardiac stem cells for the treatment of heart failure

Authors Fuentes T, Kearns-Jonker M

Received 17 November 2012

Accepted for publication 17 January 2013

Published 25 March 2013 Volume 2013:6 Pages 1—12

DOI https://doi.org/10.2147/SCCAA.S29221

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Tania Fuentes, Mary Kearns-Jonker

Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA

Abstract: Stem cell-based therapies hold promise for regenerating the myocardium after injury. Recent data obtained from phase I clinical trials using endogenous cardiovascular progenitors isolated directly from the heart suggest that cell-based treatment for heart patients using stem cells that reside in the heart provides significant functional benefit and an improvement in patient outcome. Methods to achieve improved engraftment and regeneration may extend this therapeutic benefit. Endogenous cardiovascular progenitors have been tested extensively in small animals to identify cells that improve cardiac function after myocardial infarction. However, the relative lack of large animal models impedes translation into clinical practice. This review will exclusively focus on the latest research pertaining to humans and large animals, including both endogenous and induced sources of cardiovascular progenitors.

Keywords: Isl1, iPSC, large animal, c-kit, cardiosphere

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