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Elevated body mass index as a risk factor for chronic kidney disease: current perspectives

Authors Garland J

Received 20 December 2013

Accepted for publication 3 April 2014

Published 29 July 2014 Volume 2014:7 Pages 347—355

DOI https://doi.org/10.2147/DMSO.S46674

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Jocelyn S Garland

Department of Medicine, Queen's University, Kingston, ON, Canada

Abstract: Chronic kidney disease (CKD) is defined by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative as the presence of reduced kidney function or kidney damage for a period of 3 months or greater. Obesity is considered a risk factor for CKD development, but its precise role in contributing to CKD and end stage kidney disease is not fully elucidated. In this narrative review, the objectives are to describe the pathogenesis of CKD in obesity, including the impact of altered adipokine secretion in obesity and CKD, and to provide an overview of the clinical studies assessing the risk of obesity and CKD development.

Keywords: obesity, chronic renal disease, adipokine

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