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Elevated body mass index as a risk factor for chronic kidney disease: current perspectives
Authors Garland J
Received 20 December 2013
Accepted for publication 3 April 2014
Published 29 July 2014 Volume 2014:7 Pages 347—355
DOI https://doi.org/10.2147/DMSO.S46674
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 4
Jocelyn S Garland
Department of Medicine, Queen's University, Kingston, ON, Canada
Abstract: Chronic kidney disease (CKD) is defined by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative as the presence of reduced kidney function or kidney damage for a period of 3 months or greater. Obesity is considered a risk factor for CKD development, but its precise role in contributing to CKD and end stage kidney disease is not fully elucidated. In this narrative review, the objectives are to describe the pathogenesis of CKD in obesity, including the impact of altered adipokine secretion in obesity and CKD, and to provide an overview of the clinical studies assessing the risk of obesity and CKD development.
Keywords: obesity, chronic renal disease, adipokine
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