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Efficacy of atropine combined with paroxetine in vagus nerve excitatory panic disorder

Authors Du N, Sun X

Received 13 April 2015

Accepted for publication 12 May 2015

Published 6 July 2015 Volume 2015:11 Pages 1645—1646

DOI https://doi.org/10.2147/NDT.S86544

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang

Na Du, Xue-Li Sun

Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, People’s Republic of China

Abstract: Panic disorder is often associated with the autonomic nervous system pattern – sympathetic activation and parasympathetic (vagal) withdrawal. However, we present one special case here to show a totally reversed pathogenesis – vagal activation occupying the leading role, which requires atropine to cure the patient’s symptoms. Through this report, it is reasonably proven that panic disorder may be a heterogeneous condition, whose mechanism might be the imbalance between the sympathetic and parasympathetic tone.

Keywords: panic disorder, vagal activation, bradycardia, atropine

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