Back to Journals » OncoTargets and Therapy » Volume 11

Efficacy and safety of PD1/PDL1 blockades versus docetaxel in patients with pretreated advanced non-small-cell lung cancer: a meta-analysis

Authors Liu J, Zhong Y, Peng S, Zhou X, Gan X

Received 25 July 2018

Accepted for publication 7 November 2018

Published 3 December 2018 Volume 2018:11 Pages 8623—8632


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Cho

Jixiang Liu, Yulan Zhong, Shanshan Peng, Xiangxiang Zhou, Xin Gan

Department of Respiratory Medicine, The First Affiliated Hospital, Nanchang University, Nanchang, China

Background: PD1/PDL1 blockade is a promising treatment for patients with non-small-cell lung cancer (NSCLC). Here, we employed meta-analysis to evaluate the efficacy and safety of PD1/PDL1 blockades for previously treated NSCLC patients.
Methods: Randomized clinical trials were retrieved by searching electronic databases. Data for HRs, 95% CIs for overall survival (OS), progression-free survival (PFS), and adverse events (AEs) were extracted and pooled.
Results: A total of five randomized controlled trials including 2,910 patients were included in this meta-analysis. Pooled HRs (95% CI) were 0.71 (0.63–0.79, P<0.0001) for OS and 0.86 (0.73–1.02) for PFS. In the subgroup analysis, the pooled HR (95% CI) for PFS was 0.82 (0.75–0.91, P<0.0001) in patients with high PDL1 expression, but no significant difference was seen in patients with low expression (0.97 [0.76–1.24], P=0.82). The pooled RR for treatment-related AEs of all grades was 0.32 (0.27–0.38, P<0.00001) compared with the docetaxel arm, while that for grade 3–5 treatment-related AEs in the PD1/PDL1-blockade arm was 0.16 (0.10–0.27, P<0.00001).
Conclusion: PD1/PDL1 blockades enhanced OS and PFS and led to lower risk of AEs in NSCLC patients. Smoking history and wild-type EGFR were associated with extended OS.

non-small-cell lung cancer, checkpoint immunologic treatments, PD1, PDL1, meta-analysis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]