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Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences

Authors Wang J, Xu J

Received 4 November 2019

Accepted for publication 25 February 2020

Published 13 March 2020 Volume 2020:13 Pages 719—727

DOI https://doi.org/10.2147/DMSO.S237294

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Antonio Brunetti


Jiao Wang, Jixiong Xu

Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China

Correspondence: Jixiong Xu
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng St., Nanchang, Jiangxi Province 330006, People’s Republic of China
Tel +86 13307086069
Email Jixiong.Xu@ncu.edu.cn

Abstract: Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although many studies have addressed the healing effect of systemic insulin on burn wound, only few have investigated the efficacy of topical insulin. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds. The presented animal and clinical studies support that topical insulin improves wound healing through several mechanisms without causing side effects. Additionally, various wound dressings accelerate the wound healing with controlled and sustained delivery of bioactive insulin. Therefore, topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.

Keywords: wound healing, insulin therapy, review

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