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Effects of prenatal exposure to temephos on behavior and social interaction

Authors Martins Laurentino AO, Durante de Medeiros F, de Oliveira J, da Rosa N, Mateus Gomes T, de Medeiros Peretti E, Somariva Prophiro J, Fortunato JJ

Received 5 December 2018

Accepted for publication 29 January 2019

Published 11 March 2019 Volume 2019:15 Pages 669—673

DOI https://doi.org/10.2147/NDT.S193896

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Ana Olívia Martins Laurentino,1 Fabiana Durante de Medeiros,1 Juliana de Oliveira,1,2 Naiana da Rosa,1,2 Tamires Mateus Gomes,1 Eduardo de Medeiros Peretti,1 Josiane Somariva Prophiro,1,2 Jucélia J Fortunato1,2

1Neurobiology Laboratory of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil; 2Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil

Abstract: The neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (OP). The OP is neurotoxic and has been associated with neurological diseases pathophysiology. The OP temephos is widely used against Aedes aegypti in Brazil’s public health programs.
Purpose: To evaluate behavioral effects of prenatal exposition to temephos in Wistar rats.
Methods: First, we divided pregnant females into groups: those who received temephos diluted in distilled water by gavage between gestational days 6–13 and those who received only distilled water in the same period and volume. Then, we divided pups according to sex and exposure, and we made the behavioral tests on postnatal day 30.
Results: Prenatal exposure to temephos caused hyperactivity, stereotyped behavior, and social impairment in animals.
Conclusion: These results are similar to the altered behavior presented in some neurobiological diseases models, like Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders, and this study may bring a red alert to the large use of temephos in Brazil, due to the damage caused by its exposure.

Keywords: neurodevelopment, organophosphate, toxicity, temephos
 

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