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Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats

Authors Folwarczna J, Konarek N, Freier K, Karbowniczek D, Londzin P, Janas A

Received 11 May 2019

Accepted for publication 26 July 2019

Published 23 September 2019 Volume 2019:13 Pages 3357—3367

DOI https://doi.org/10.2147/DDDT.S215337

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Nicola Ludin

Peer reviewer comments 2

Editor who approved publication: Dr Georgios D. Panos


Joanna Folwarczna, Natalia Konarek, Karolina Freier, Dawid Karbowniczek, Piotr Londzin, Aleksandra Janas

Department of Pharmacology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Sosnowiec 41-200, Poland

Correspondence: Joanna Folwarczna
Department of Pharmacology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland
Tel +48 32 364 1540
Fax +48 32 364 1540
Email jfolwarczna@sum.edu.pl

Background: Histamine H1 receptor antagonists are widely used in the treatment of allergic diseases. H1 receptors are expressed on bone cells and histamine takes part in regulation of bone metabolism. Loratadine is often prescribed to children.
Purpose: The aim of the present study was to investigate the effects of loratadine on the skeletal system of young rats.
Material and methods: Loratadine (0.5, 5, and 50 mg/kg p.o. daily) was administered for 4 weeks to male Wistar rats, 6-week-old at the start of the experiment. Bone mass, mass of bone mineral, calcium, and phosphorus content in the bone mineral of the tibia, femur, and L-4 vertebra, histomorphometric parameters of the femur, mechanical properties of the proximal tibial metaphysis, femoral diaphysis and femoral neck, and serum levels of bone turnover markers were examined.
Results: Loratadine at 0.5 and 5 mg/kg did not significantly affect the skeletal system of young rats. At 50 mg/kg, loratadine decreased the femoral length, increased content of calcium and phosphorus in the bone mineral of the vertebra, and tended to improve mechanical properties of the tibial metaphysis.
Conclusion: High-dose loratadine slightly but significantly affected development of the skeletal system in rapidly growing rats.

Keywords: loratadine, histamine H1 receptor antagonists, bone, rats

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