Effective treatment with icotinib in lung adenocarcinoma with EGFR and ALK co-alterations and brain metastasis
Authors Ye CY, Wang J, Zheng S, Chai Y
Received 9 September 2016
Accepted for publication 7 October 2016
Published 26 October 2016 Volume 2016:9 Pages 6605—6608
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Ingrid Espinoza
Chenyang Ye,1,* Ji Wang,2,* Shu Zheng,1 Ying Chai3
1Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, 2Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, 3Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
*These authors contributed equally to this work
Abstract: We report a rare case of advanced lung cancer with epidermal growth factor receptor and anaplastic lymphoma kinase co-alterations and brain metastasis, in which icotinib treatment was effective for both the primary lung tumor and the brain metastasis. The patient achieved important clinical remission with a progression-free survival for two years. Our treatment strategy appears to be a promising therapeutic approach for this subgroup of patients.
Keywords: lung cancer, brain metastasis, EGFR, ALK, icotinib
Central nervous system (CNS) metastasis from non-small cell lung cancer (NSCLC) is a devastating complication, resulting in reduced quality of life and shortened survival. Molecular evaluation of primary lung cancer is needed for targeted treatment. We describe a case of advanced lung cancer with concurrent epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangements, in which both the primary lung lesion and the brain metastasis (BM) showed remarkable responses to icotinib.
In June 2014, a 62-year-old Chinese male heavy smoker presented to our hospital with recurrent cough and blood-stained sputum. His previous medical history was unremarkable. Physical examination and laboratory test results showed no significant abnormalities. The chest computed tomographic scan revealed a 3.7×2.8 cm mass in the left lower lung (LLL) (Figure 1). Mediastinal and hilar lymph nodes were not enlarged. A bronchoscopic biopsy was performed, and histopathologic examination confirmed NSCLC with a moderately differentiated tumor histology favoring adenocarcinoma (Figure 2). Subsequent brain magnetic resonance imaging (MRI) indicated BM (Figure 1). Thus, we made a diagnosis of stage IV lung adenocarcinoma with metastasis to brain according to the 7th American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) tumor staging system. In light of the patient’s advanced age, a history of heavy smoking for over thirty years, and advanced NSCLC with BM, surgical resection for either primary LLL lesion or BM was not feasible. The patient refused to undergo chemotherapy or radiotherapy. EGFR mutation and ALK translocation status were identified by direct Sanger sequencing, real-time polymerase chain reaction, and fluorescence in situ hybridization (FISH) analysis, and both were found to be positive (EGFR exon 21 L858R and ALK FISH positive 22% of the cells) (Figure 3A and B). The patient began receiving 375 mg icotinib once daily. A repeated computed tomography (CT) after one month of therapy disclosed that the left lung mass had partially resolved (Figure 1). The patient continued icotinib treatment. In July 2015, a follow-up thoracic CT performed after one year of icotinib therapy revealed dramatic shrinkage of the LLL lesion (Figure 1). Interestingly, brain MRI showed that the intracranial lesion had vanished entirely. He is currently still receiving icotinib treatment, and no recurrence or progression occurred with a progression-free survival for two years.
Figure 2 Histology of the primary lung cancer. The hematoxylin and eosin staining revealed that the left lower lobe lesion was a moderately differentiated adenocarcinoma (magnification ×100).
The CNS is a common site for NSCLC metastasis, with approximately 30% to 50%1 of all NSCLC patients ultimately developing BM. Despite recent therapeutic advances, the development of BM from NSCLC remains a significant challenge in treatment. Surgical resection and radiotherapy including whole-brain radiotherapy and stereotactic radiosurgery are currently the most common strategies in the treatment of BM. However, the long-term prognosis of NSCLC patients with BM remains poor, with a median survival of seven months.2
Recently, molecular targeted treatments have improved the overall survival of advanced NSCLC patients with specific mutations.3 Several studies indicate that molecular targeted therapies, particularly EGFR-tyrosine kinase inhibitors (TKIs)4 and crizotinib,5 can achieve objective responses of both primary tumors and BM lesions in some patients with EGFR-mutated or ALK-rearranged advanced NSCLC. However, effective treatment for NSCLC with EGFR/ALK co-alterations and BM was scarcely reported. EGFR mutations and ALK rearrangements are generally considered mutually exclusive6 in NSCLC, and only a few cases have been described in the literature.7,8 The best treatment for advanced pulmonary adenocarcinomas with coexisting EGFR mutation and ALK rearrangements remains unclear, because diverse responses to EGFR-TKIs and crizotinib have been previously reported.9 Icotinib, an oral EGFR-TKI, has been proved to be non-inferior to gefitinib therapy in patients with NSCLC.10 Our patient was prescribed icotinib treatment, and he attained a partial response in the primary left lung lesion and a complete remission in the intracranial metastasis. This rare case obtained important clinical remissions in the primary tumor as well as in the brain lesion for NSCLC patients with dual EGFR/ALK mutations and BM, providing new evidence for targeted therapy in this clinical setting.
In summary, we present an extremely rare case of advanced lung adenocarcinoma harboring concomitant EGFR mutation and ALK arrangements, in which both the primary lung lesion and the BM responded well to EGFR-TKI treatment. The patient experienced a long-standing response to icotinib with a progression-free survival for two years. This case indicates that molecular evaluation of primary tumor is warranted to test for known driver mutations in the management of advanced NSCLC with BM, providing opportunities for molecular targeted therapy. Our present case provides insight into the efficacy of icotinib for advanced NSCLC patients with co-altered EGFR and ALK. However, further studies to clarify the underlying biological mechanism of EGFR-TKI efficacy and the optimal targeted therapy in this patient population are warranted.
The patient provided written informed consent to publish their data and images in this report. The authors thank all the group members for helpful discussions. This work was supported by grants to Y Chai from the Science and Technology Department of Zhejiang Province (2013c03044–7) and the Natural Science Foundation of Zhejiang Province (LY13H160016).
The authors report no conflicts of interest in this work.
Patchell RA. The management of brain metastases. Cancer Treat Rev. 2003;29(6):533–540.
Sperduto PW, Chao ST, Sneed PK, et al. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys. 2010;77(3):655–661.
Zhang I, Zaorsky NG, Palmer JD, Mehra R, Lu B. Targeting brain metastases in ALK-rearranged non-small-cell lung cancer. Lancet Oncol. 2015;16(13):e510–e521.
Porta R, Sanchez-Torres JM, Paz-Ares L, et al. Brain metastases from lung cancer responding to erlotinib: the importance of EGFR mutation. Eur Respir J. 2011;37(3):624–631.
Costa DB, Shaw AT, Ou SH, et al. Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases. J Clin Oncol. 2015;33(17):1881–1888.
Gainor JF, Varghese AM, Ou SH, et al. ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer. Clin Cancer Res. 2013;19(15):4273–4281.
Kuo YW, Wu SG, Ho CC, Shih JY. Good response to gefitinib in lung adenocarcinoma harboring coexisting EML4-ALK fusion gene and EGFR mutation. J Thorac Oncol. 2010;5(12):2039–2040.
Chiari R, Duranti S, Ludovini V, et al. Long-term response to gefitinib and crizotinib in lung adenocarcinoma harboring both epidermal growth factor receptor mutation and EML4-ALK fusion gene. J Clin Oncol. 2014;32(9):e30–e32.
Yang JJ, Zhang XC, Su J, et al. Lung cancers with concomitant EGFR mutations and ALK rearrangements: diverse responses to EGFR-TKI and crizotinib in relation to diverse receptors phosphorylation. Clin Cancer Res. 2014;20(5):1383–1392.
Shi Y, Zhang L, Liu X, et al. Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial. Lancet Oncol. 2013;14(10):953–961.
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