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Effect of preoperative pregabalin on analgesia and interleukins after lumbotomy: prospective, randomized, comparative, double-blind study

Authors Santiago AEQ, Leal PC, Moura ECR, Salomão R, Brunialti MKC, Sakata RK

Received 2 October 2018

Accepted for publication 8 December 2018

Published 11 January 2019 Volume 2019:12 Pages 339—344

DOI https://doi.org/10.2147/JPR.S189441

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr E Alfonso Romero-Sandoval


Ana Ellen Queiroz Santiago, Plinio da Cunha Leal, Ed Carlos Rey Moura, Reinaldo Salomão, Milena Karina Coló Brunialti, Rioko Kimiko Sakata

Department of Anesthesia, Universidade Federal de São Paulo, São Paulo, Brazil

Background: Pregabalin is an anticonvulsant and has been used for postoperative analgesia. This study aimed to assess the effect of a single preoperative dose of pregabalin for analgesia after nephrectomy.
Methods: The study was prospective, randomized, comparative, and double-blinded, conducted in 40 kidney transplant donors, between 18 and 60 years, American Society of Anesthesia physical status I or II. Epidural anesthesia was performed with 15 mL of 0.5% ropivacaine single shot and general anesthesia with 3 µg/kg of fentanyl, propofol, atracurium, and sevoflurane, and 50% of oxygen without nitrous oxide. Patients in group 1 were administered 300 mg of pregabalin and those in group 2 were administered placebo, in identical capsules, 1 hour prior to surgery. Postoperative analgesia was supplemented with tramadol. The following parameters were assessed: pain intensity after 6 and 24 hours; pain threshold, from the thenar and peri-incisional region, analgesic supplementation; ILs (IL6, IL8, and IL10) prior to surgery and after 6 and 24 hours.
Results: The pain intensity was lower with pregabalin after 24 hours (G1: 2.5±2.4, G2: 3.0±2.6). There was no difference in the sensitivity of the thenar and peri-incisional region after 6 and 24 hours; in the number of patients requiring supplementation (G1=15%, G2=45%); concentrations of IL-6, IL-8, and IL-10; and side effects (nausea, vomiting, dizziness, and pruritus).
Conclusion: Pregabalin in a single preoperative dose of 300 mg reduced pain intensity 24 hours after lumbotomy.

Keywords: pregabalin, lumbotomy, postoperative analgesia, kidney transplant, nephrectomy

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