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Dyslipidemia and Associated Factors Among Patients Suspected to Have Helicobacter pylori Infection at Jimma University Medical Center, Jimma, Ethiopia

Authors Abdu A, Cheneke W, Adem M, Belete R, Getachew A

Received 26 December 2019

Accepted for publication 1 April 2020

Published 17 June 2020 Volume 2020:13 Pages 311—321

DOI https://doi.org/10.2147/IJGM.S243848

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Ahmedmenewer Abdu,1 Waqtola Cheneke,2 Mohammed Adem,3 Rebuma Belete,1 Aklilu Getachew2

1Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Medical Laboratory Sciences, College of Health Sciences, Jimma University, Jimma, Ethiopia; 3Medical Laboratory Service, Clinical Chemistry Unit, Jimma University Medical Center, Jimma, Ethiopia

Correspondence: Ahmedmenewer Abdu
Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, PO Box 235, Harar, Ethiopia
Tel +251 922618955
Email menewer59@gmail.com

Background: Dyslipidemia is a group of plasma lipid and lipoprotein abnormality that is metabolically associated, and it is categorized by low HDL-C and increased LDL-C, TGs, and total cholesterol (TC) levels. Colonization of the stomach by Helicobacter pylori (H. pylori) causes chronic inflammation of the stomach wall which can change some biochemical factors in the patient. On the association of H. pylori infection and its contributions to change in serum lipid profile, different studies reported varying outcomes.
Objective: To assess the prevalence of dyslipidemia and associated factors among patients suspected for H. pylori infection in the outpatient department of Jimma University Medical Center, Jimma, Ethiopia.
Materials and Methods: A hospital-based cross-sectional study was conducted from January 03 to April 05, 2019, at Jimma University Medical Center on 369 H. pylori suspected patients. The study subjects were selected by convenient sampling technique. About 5mL of blood was collected from an overnight fasting individual. Data were edited, coded, and entered into Epidata version 3.1 and exported to (SPSS) version 25 for analysis. Bivariate analysis was used to screen those variables which were candidates for multivariate analysis.
Results: From the total study subjects 77.5% had at least one abnormality in lipid profile and 87.2% of H. pylori positive patients had at least one abnormality in lipid profile. Our study demonstrated that there was significant increase of mean ± SD of TC, TG, and LDL-C in H. pylori positive patients than H. pylori negative patients (P-value < 0.05). After adjusting for traditional dyslipidemia risk factors, H. pylori infection was an independent predictor of dyslipidemia (AOR 2.628, 95% CI 1.477– 4.678, P=0.001).
Conclusion: An increase in prevalence of dyslipidemia among H. pylori positive patients indicates H. pylori infected patients have a possibility of altered lipid profile, therefore assessment of lipid profile in H. pylori infected patients is recommended.

Keywords: Helicobacter pylori infection, lipid profile, Jimma, Ethiopia

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