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Dynamic Changes in Serum Inhibin B Levels in 6- to 24-Month-Old Children Receiving Cryptorchidism Surgery

Authors Ma D, Yao ZG, Guo YP, Wu RF

Received 11 January 2021

Accepted for publication 5 March 2021

Published 31 March 2021 Volume 2021:14 Pages 1173—1177

DOI https://doi.org/10.2147/IJGM.S301546

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Da Ma, Zhi-Guang Yao, Yan-Ping Guo, Rui-Fa Wu

Department of Pediatric General Surgery, Dongguan Eighth People’s Hospital (Dongguan Children’s Hospital), Dongguan, 523000, People’s Republic of China

Correspondence: Da Ma
Department of Pediatric General Surgery, Dongguan Eighth People’s Hospital (Dongguan Children’s Hospital), Dongguan, People’s Republic of China
Tel/Fax +86 769-86186253
Email [email protected]

Objective: Cryptorchidism is the most common congenital disability and is defined as the absence of one or both testicles in the scrotum during fetal development. In patients with cryptorchidism, lowered serum inhibin B levels suggest testicular dysfunction. The practical application of serum inhibin B levels in childhood remains controversial. The purpose of this study was to observe the post-operational changes of serum inhibin B levels in patients with cryptorchidism and provide evidence that serum inhibin B is a potential marker for the efficacy of testicular surgery.
Methods: A total of 83 male children with cryptorchidism were enrolled in this study. All the children had blood samples taken by venipuncture on the day of surgery. The serum inhibin B levels in the blood samples were measured using an ELISA kit. Paired t-tests were used to assess differences between the groups.
Results: The results show that, compared with the preoperative values, there was a statistically significant increase in serum inhibin B values one month after the operation in each group (P < 0.05). Compared with the one-month post-operation results, there were no significant changes six months after operation in each group (P> 0.05). However, serum inhibin B values decreased significantly in all groups at 12 months post-operation (P < 0.05), suggesting that serum inhibin B values are significantly correlated with age. Correlation analysis showed that serum inhibin B was negatively correlated with age from 6 to 36 months, and the correlation coefficient was − 0.488.
Conclusion: Serum inhibin B can be used as a short-term evaluation index of cryptorchidism surgery rather than as a long-term indicator.

Keywords: serum inhibin B, children, cryptorchidism surgery

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