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Dorsal root ganglion – a potential new therapeutic target for neuropathic pain

Authors Sapunar D, Sandra Kostic, Banozic A, Puljak L

Received 29 September 2011

Accepted for publication 22 October 2011

Published 16 February 2012 Volume 2012:5 Pages 31—38


Review by Single-blind

Peer reviewer comments 3

Damir Sapunar, Sandra Kostic, Adriana Banozic, Livia Puljak

Department of Anatomy, Histology, and Embryology, University of Split Medical School, Soltanska 2, 21000 Split, Croatia

Abstract: A regional approach can protect our patients from often unacceptable adverse effects produced by systematically applied drugs. Regional therapeutic approaches, as well as interventions at the level of the peripheral nervous system and particularly the dorsal root ganglion (DRG), represent an alternative to the systemic application of therapeutic agents. This article provides an overview of DRG anatomical peculiarities, explains why the DRG is an important therapeutic target, and how animal models of targeted drug delivery can help us in the translation of basic research into clinical practice.

Keywords: dorsal root ganglion, neuropathic pain, pain therapy, targeted drug delivery

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