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Does amantadine induce acute psychosis? A case report and literature review

Authors xu W, Wei N, Xu Y, Hu S

Received 30 November 2015

Accepted for publication 16 February 2016

Published 6 April 2016 Volume 2016:12 Pages 781—783

DOI https://doi.org/10.2147/NDT.S101569

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang


Wei-juan Xu,1,2 Ning Wei,1,2 Yi Xu,1,2 Shao-hua Hu1,2

1Department of Psychiatry, The First Affiliated Hospital of Zhejiang University School of Medicine, 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China

Background: Over-the-counter cold medicines, which contain amantadine, are widely used in the People’s Republic of China. Clinicians are familiar with the psychosis caused by long-term treatment with amantadine, especially in elderly patients; however, early-onset psychotic complications among healthy young individuals have rarely been reported.
Case presentation: This article reports the case of a 28-year-old patient who presented with hallucination–delusion syndrome soon after treatment with cold medicine containing amantadine hydrochloride and acetaminophen. The symptoms resolved completely after a 2-week course of paliperidone treatment.
Conclusion: Clinicians should be sensitive to the acute psychotic complications induced by an interaction between amantadine and acetaminophen.

Keywords: amantadine, acetaminophen, side effects

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