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Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study

Authors Huang X, Cai F, Hu P, Zhong Y, Zhang Y, Wei R, Pei C, Zhou F, Shao Y

Received 16 July 2015

Accepted for publication 22 October 2015

Published 16 December 2015 Volume 2015:11 Pages 3075—3083

DOI https://doi.org/10.2147/NDT.S92497

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Xiang Mou

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang

Xin Huang,1,2,* Feng-Qin Cai,3,* Pei-Hong Hu,1 Yu-Lin Zhong,1 Ying Zhang,1 Rong Wei,1 Chong-Gang Pei,1 Fu-Qing Zhou,3 Yi Shao1

1Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, First People’s Hospital of Jiujiang, Jiujiang, 3Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China

*These authors contributed equally to this work

Objective: To use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the local features of spontaneous brain activity in optic neuritis (ON) and their relationship with behavioral performance.
Materials and methods: Twelve patients with ON (four male, eight female) and twelve age-, sex-, and education status-matched healthy controls (HCs) (four male, eight female) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The ALFF technique was used to assess local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ALFF values of the different areas and visual evoked potentials (VEPs) in patients with ON.
Results: Compared with HCs, patients with ON had significantly decreased ALFF values in the posterior and anterior lobes of the right cerebellum, right putamen, right inferior frontal gyrus, right insula, right supramarginal gyrus, right inferior parietal lobule, left medial frontal gyrus, left superior temporal gyrus, bilateral anterior cingulate/medial frontal gyrus, and bilateral precuneus, and significantly increased ALFF values in the posterior lobes of the left and right cerebellum, right inferior temporal gyrus, right inferior temporal/fusiform gyrus, left parahippocampal gyrus, left fusiform gyrus, left calcarine fissure, left inferior parietal lobule, and left cuneus. We found negative correlations between the mean ALFF signal value of the left parahippocampal gyrus and the VEP amplitude of the right eye in ON (r=-0.584, P=0.046), and a positive correlation between the mean ALFF signal value of the bilateral precuneus and the best-corrected visual acuity of the left eye (r=0.579, P=0.048) in patients with ON.
Conclusion: ON mainly seems to involve dysfunction in the default-mode network, cerebellum, and limbic system, which may reflect the underlying pathologic mechanism of ON.

Keywords: ALFF, fMRI, optic neuritis, resting state, spontaneous activity, visual evoked potential
 

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