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Disrupted resting-state spontaneous neural activity in stable COPD

Authors Xin H, Li H, Yu H, Yu J, Zhang J, Wang W, Peng D

Received 12 October 2018

Accepted for publication 17 January 2019

Published 27 February 2019 Volume 2019:14 Pages 499—508

DOI https://doi.org/10.2147/COPD.S190671

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Chunxue Bai


Huizhen Xin,1,* Haijun Li,1,* Honghui Yu,1 Jingjing Yu,2 Juan Zhang,1 Wenjing Wang,2 Dechang Peng1

1Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China; 2Department of Respiratory, The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China

*These authors contributed equally to this work

Introduction and aim: Abnormal brain structure and function in COPD has been reported on MRI. However, the deficit in local synchronization of spontaneous activity in patients with stable COPD remains unknown. The main aim of the present study was to explore spontaneous brain activity in patients with COPD compared with normal controls using the regional homogeneity (ReHo) method based on resting-state functional MRI.
Methods: Nineteen patients with stable COPD and 20 well-matched (including age, sex, and number of years of education) normal controls who were recruited for the present study underwent resting-state functional MRI examinations and a series of neuropsychological and clinical assessments. The ReHo method was used to assess the strength of local brain signal synchrony. The mean ReHo values in brain areas with abnormal ReHo were evaluated with a receiver operating characteristic curve. The relationships between the brain regions with altered ReHo values and the clinical and neuropsychological parameters in COPD patients were assessed using Pearson’s correlation.
Results: Patients with COPD showed significantly lower ReHo values in the left occipital lobe and the right lingual, bilateral precuneus, and right precentral gyrus. The result of receiver operating characteristic curve analysis showed that the altered average ReHo values have high efficacy for distinguishing function. The mean lower ReHo values in the precuneus gyrus showed a significant positive correlation with FEV1%, FEV1/FVC, and orientation function but a significant negative correlation with arterial partial pressure of carbon dioxide.
Conclusion: The COPD patients demonstrated abnormal synchrony of regional spontaneous activity, and the regions with abnormal activity were all correlated with visual processing pathways, which might provide us with a new perspective to further understand the underlying pathophysiology of cognitive impairment in patients with COPD.

Keywords: chronic obstructive pulmonary disease, regional homogeneity, resting-state functional magnetic resonance imaging, visual processing pathways, blood oxygen-level-dependent


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