Back to Journals » Neuropsychiatric Disease and Treatment » Volume 11

Disconnection of the hippocampus and amygdala associated with lesion load in relapsing–remitting multiple sclerosis: a structural and functional connectivity study

Authors Zhou F, Zhuang Y, Wang L, Zhang Y, Wu L, Zeng X, Gong H

Received 14 March 2015

Accepted for publication 18 May 2015

Published 17 July 2015 Volume 2015:11 Pages 1749—1765


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang

Fuqing Zhou,1,2,* Ying Zhuang,3,* Lingling Wang,4 Yue Zhang,5 Lin Wu,1,2 Xianjun Zeng,1,2 Honghan Gong1,2

1Department of Radiology, The First Affiliated Hospital, Nanchang University, 2Jiangxi Province Medical Imaging Research Institute, 3Department of Oncology, The Second Hospital of Nanchang, Nanchang, Jiangxi Province, 4Department of Geriatrics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, 5Department of Radiology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, People’s Republic of China

*These authors contributed equally to this work

Background and purpose: Little is known about the functional and structural connectivity (FC and SC) of the hippocampus and amygdala, which are two important structures involved in cognitive processes, or their involvement in relapsing–remitting multiple sclerosis (RRMS). In this study, we aimed to examine the connectivity of white-matter (WM) tracts and the synchrony of intrinsic neuronal activity in outer regions connected with the hippocampus or amygdala in RRMS patients.
Patients and methods: Twenty-three RRMS patients and 23 healthy subjects participated in this study. Diffusion tensor probabilistic tractography was used to examine the SC, the FC correlation coefficient (FC-CC) and combined FC strength (FCS), which was derived from the resting-state functional magnetic resonance imaging used to examine the FC, of the connection between the hippocampus or the amygdala and other regions, and the correlations of these connections with clinical markers.
Results: Compared with healthy subjects, the RRMS patients showed significantly decreased SC and increased FCS of the bilateral hippocampus, and left amygdala. Their slightly increased FC-CC was positively correlated with WM tract damage in the right hippocampus (ρ=0.57, P=0.005); an increased FCS was also positively correlated with WM tract damage in the right amygdala. A relationship was observed between the WM lesion load and SC alterations, including the lg(N tracts) of the right hippocampus (ρ=-0.68, P<0.05), lg(N tracts) (ρ=-0.69, P<0.05), and fractional anisotropy (ρ=-0.68, P<0.05) and radial diffusivity of the left hippocampus (ρ=0.45, P<0.05). A relationship between WM lesion load and FCS of the left amygdale was also observed.
Conclusion: The concurrent increased functional connections and demyelination-related structural disconnectivity between the hippocampus or amygdala and other regions in RRMS suggest that the functional–structural relationships require further investigation.

Keywords: relapsing–remitting multiple sclerosis, hippocampus, limbic system, functional connectivity, structural connectivity, fiber tractography

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Altered perfusion of the sensorimotor cortex in patients with cervical spondylotic myelopathy: an arterial spin labeling study

Zhou F, Huang M, Wu L, Tan Y, Guo J, Zhang Y, He L, Gong H

Journal of Pain Research 2018, 11:181-190

Published Date: 11 January 2018

Altered low-frequency oscillation amplitude of resting state-fMRI in patients with discogenic low-back and leg pain

Zhou F, Gu L, Hong S, Liu J, Jiang J, Huang M, Zhang Y, Gong H

Journal of Pain Research 2018, 11:165-176

Published Date: 9 January 2018

Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia

Huang S, Zhou F, Jiang J, Huang M, Zeng X, Ding S, Gong H

Neuropsychiatric Disease and Treatment 2017, 13:1449-1462

Published Date: 6 June 2017

Success with neurotropin in treating pediatric lower extremity pain induced by spinal cord injury after epidural anesthesia

Zhu MY, Zhou F, Li L, Yin Q, Qiu M, Zhang Y

Journal of Pain Research 2017, 10:1391-1394

Published Date: 6 June 2017

Altered homotopic connectivity in postherpetic neuralgia: a resting state fMRI study

Jiang J, Gu LL, Bao D, Hong SD, He W, Tan YM, Zeng XJ, Gong HH, Zhang DY, Zhou FQ

Journal of Pain Research 2016, 9:877-886

Published Date: 31 October 2016

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Individual correlates of self-stigma in patients with anxiety disorders with and without comorbidities

Ociskova M, Prasko J, Kamaradova D, Grambal A, Sigmundova Z

Neuropsychiatric Disease and Treatment 2015, 11:1767-1779

Published Date: 17 July 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010