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Dietary patterns in relation to hepatic fibrosis among patients with nonalcoholic fatty liver disease

Authors Soleimani D, Ranjbar G, Rezvani R, Goshayeshi L, Razmpour F, Nematy M

Received 18 December 2018

Accepted for publication 11 February 2019

Published 12 March 2019 Volume 2019:12 Pages 315—324

DOI https://doi.org/10.2147/DMSO.S198744

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Video abstract presented by Golnaz Ranjbar.

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Davood Soleimani,1 Golnaz Ranjbar,1,2 Reza Rezvani,1,3 Ladan Goshayeshi,4 Farkhonde Razmpour,1 Mohsen Nematy1

1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Department of Biological and Environmental Sciences, Faculty of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK; 3School of Nutrition, Faculté des Sciences de l’agriculture et de l’alimentation, Université Laval, Quebec, QC, Canada; 4Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Background: Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disorder that can progress to fibrosis. Several dietary patterns have been associated with histological features of NAFLD. However, little is known about the association between dietary patterns and hepatic fibrosis.
Purpose: The current study aimed at identifying the relationship between major dietary patterns and hepatic fibrosis among patients with NAFLD.
Subjects and methods: This cross-sectional study included 170 eligible subjects with NAFLD. Diet was evaluated using three 3-day dietary records during a 1-month period. Hepatic fibrosis was diagnosed using Fibroscan. Western, Iranian, and healthy dietary patterns were extracted using factor analysis.
Results: After adjustment for other risk factors, adherence to a Western dietary pattern was associated with the higher odds of fibrosis (OR: 4.21; 95% CI: 1.63–8.31), whereas adherence to a healthy dietary pattern was associated with the lower odds of fibrosis (OR: 0.26; 95% CI: 0.10–0.49). Among main food groups, high intake of red meat, hydrogenated fats, and soft drinks was associated with the higher risk of fibrosis, whereas tea and coffee consumption had a protective role in hepatic fibrosis independent of other risk factors.
Conclusion: The adherence to a healthy dietary pattern characterized by high intake of low-fat dairies, white meat, nuts, vegetables, fruits, and vegetable oils combined with coffee and tea consumption might be helpful in the nutritional strategies against hepatic fibrosis.

Keywords: liver diseases, NAFLD, fibrosis, factor analysis, diet, dietary pattern



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