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Diagnostic Accuracy of Interleukin-27 in Bronchoalveolar Lavage Fluids for Pulmonary Tuberculosis

Authors Lin S, Wang Y, Li Y, Xiao D, Guo J, Ma W, An W, Liu H, Shi Y, Zhang L, Cui J, Guan W

Received 16 September 2019

Accepted for publication 22 November 2019

Published 2 December 2019 Volume 2019:12 Pages 3755—3763

DOI https://doi.org/10.2147/IDR.S231215

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Professor Suresh Antony


Shan Lin,1,2,* Yan Wang,1,* Yuhong Li,1 Di Xiao,1 Jin Guo,1 Weixiu Ma,1 Wenjing An,1 Hongqian Liu,1 Yingqing Shi,1 Lei Zhang,1 Jingxia Cui,1 Wei Guan1,3,*

1Department of Respiratory Medicine, Qinghai University Affiliated Hospital, Xining 810001, People’s Republic of China; 2Department of Medical Intensive Care Unit, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, GuangDong 510080, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Baoan Central Hospital of Shenzhen/The Fifth Affiliated Hospital of Shenzhen University, Shenzhen, GuangDong 518102, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Wei Guan
Department of Respiratory and Critical Care Medicine, Baoan Central Hospital of Shenzhen/The Fifth Affiliated Hospital of Shenzhen University, 60 Xixiang Leyuan Street, Shenzhen, GuangDong 518102, People’s Republic of China
Email weiguan110@163.com
Jingxia Cui
Department of Respiratory Medicine, Qinghai University Affiliated Hospital, Xining 810001, People’s Republic of China
Email Cui97213576@163.com

Background: The World Health Organization states that China had 0.9 million cases of tuberculosis in 2017, accounting for 9% of cases globally. Despite a decrease in the incidence and mortality of tuberculosis in China over time, development in choosing the appropriate prevention and control of TB is required.
Purpose: The aim of this study was to evaluate the diagnostic significance of interleukin-27 in bronchoalveolar lavage fluids for pulmonary tuberculosis.
Materials and methods: Eventually, 107 bronchoalveolar lavage fluids from patients were included in this study. The concentrations of interleukin-27 and adenosine deaminase were determined in bronchoalveolar lavage fluids using enzyme-linked immunosorbent assay.
Results: It was found that the concentrations of interleukin-27 in bronchoalveolar lavage fluids of sputum-positive pulmonary tuberculosis group were significantly higher than those in sputum-negative pulmonary tuberculosis, lung cancer, and previous pulmonary tuberculosis groups, respectively (all P<0.001). Interleukin-27 levels in bronchoalveolar lavage fluids could be used for diagnostic purpose for pulmonary tuberculosis, with the cutoff value of 7.867 pg/mL; interleukin-27 had a sensitivity of 68.8% and specificity of 100% for the differential diagnosis of pulmonary tuberculosis (sputum-negative and sputum-positive PTB) from lung cancer. And with the cutoff value of 6.012 pg/mL, IL-27 had sensitivity and specificity of both 100% for the differential diagnosis of PTB from previous PTB. The risk of pulmonary tuberculosis was positively associated with the concentrations of interleukin-27 and adenosine deaminase in bronchoalveolar lavage fluids.
Conclusion: Interleukin-27 in bronchoalveolar lavage fluids is a sensitive and specific biomarker for the differential diagnosis of pulmonary tuberculosis from lung cancer and previous pulmonary tuberculosis.

Keywords: pulmonary tuberculosis, interleukin-27, adenosine deaminase, bronchoalveolar lavage fluid

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