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Determinants of multidrug-resistant tuberculosis in Addis Ababa, Ethiopia

Authors Assefa D, Seyoum B, Oljira L

Received 9 February 2017

Accepted for publication 7 April 2017

Published 11 July 2017 Volume 2017:10 Pages 209—213

DOI https://doi.org/10.2147/IDR.S134369

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Suresh Antony

Demelash Assefa,1 Berhanu Seyoum,2 Lemessa Oljira2

1KNCV Tuberculosis Foundation, Addis Ababa, 2School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia

Abstract: Multidrug-resistant tuberculosis (MDR-TB) has been jeopardizing the global effort to prevent and control tuberculosis (TB). However, data on MDR-TB in Ethiopia in general, and in our study area in particular, are very scarce. The aim of this study was to identify determinants of MDR-TB in a cohort of patients managed in two referral hospitals of Addis Ababa, Ethiopia, between April 1, 2013 and June 30, 2013. A health facility-based case–control study was conducted. A total of 710 TB patients (229 confirmed MDR-TB and 481 drug susceptible TB patients) were enrolled in this study. Identified independent determinants for MDR-TB were contact history with a known TB patient (adjusted odds ratio [AOR]: 1.9, 95% CI: 1.1–3.3), previous history of TB treatment (AOR: 11.9, 95% CI: 6.8–21), history of hospitalization (AOR: 4.4 95% CI: 2.2–7.8), sputum-smear positivity (AOR: 1.9, 95% CI: 1.1–3.4), and social stigma (AOR: 5.1, 95% CI: 1.8–14.4). These identified factors should be considered for use in MDR-TB screening tool development if universal drug susceptibility testing is not possible. Moreover, TB infection control practices in health care settings should be further strengthened. As factors may vary from region to region, further broader studies need to be conducted in other parts of Ethiopia.

Keywords: MDR-TB, drug susceptible TB, determinants, sputum smear positive, treatment completed, cured, drug susceptibility testing

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