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Decreasing glioma recurrence through adjuvant cancer stem cell inhibition

Authors Neman J, Jandial R

Published 22 June 2010 Volume 2010:4 Pages 157—162

DOI https://doi.org/10.2147/BTT.S9497

Review by Single-blind

Peer reviewer comments 2


Josh Neman, Rahul Jandial

Division of Neurosurgery, City of Hope National Cancer Center, Duarte, CA, USA

Abstract: Gliomas remain one of the most challenging solid organ tumors to treat and are marked clinically by invariable recurrence despite multimodal intervention (surgery, chemotherapy, radiation). This recurrence perhaps, is as a consequence of the failure to eradicate a tumor cell subpopulation, termed cancer stem cells. Isolating, characterizing, and understanding these tumor-initiating cells through cellular and molecular markers, along with genetic and epigenetic understanding will allow for selective targeting through therapeutic agents and holds promise for decreasing glioma recurrence.
Keywords: glioma, cancer stem cells, epigenetic

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