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Daptomycin: a novel lipopeptide antibiotic against Gram-positive pathogens

Authors Beiras-Fernandez A, Vogt F, Sodian R, Weis F

Published 30 August 2010 Volume 2010:3 Pages 95—101

DOI https://doi.org/10.2147/IDR.S6961

Review by Single-blind

Peer reviewer comments 2

Andres Beiras-Fernandez1,*, Ferdinand Vogt1,*, Ralf Sodian1, Florian Weis2

1Department of Cardiac Surgery, University Hospital Großhadern, Ludwig-Maximilian-University, Munich, Germany; 2Department of Anesthesiology, University Hospital Großhadern, Ludwig-Maximilian-University, Munich, Germany *Andres Beiras-Fernandez and Ferdinand Vogt contributed equally to this paper

Abstract: The aim of this review is to summarize the historical background of drug resistance of Gram-positive pathogens as well as to describe in detail the novel lipopeptide antibiotic daptomycin. Pharmacological and pharmacokinetic aspects are reviewed and the current clinical use of daptomycin is presented. Daptomycin seems to be a reliable drug in the treatment of complicated skin and skin structure infections, infective right-sided endocarditis, and bacteremia caused by Gram-positive agents. Its unique mechanism of action and its low resistance profile, together with its rapid bactericidal action make it a favorable alternative to vancomycin in multi-drug resistant cocci. The role of daptomycin in the treatment of prosthetic material infections, osteomyelitis, and urogenital infections needs to be evaluated in randomized clinical trials.

Keywords: daptomycin, multi-drug resistance, methicillin-resistant Staphylococcus aureus (MRSA), pneumonia, urinary tract infection, left-sided endocarditis

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