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CYFRA 21-1 in urine: a diagnostic marker for endometriosis?

Authors Gjavotchanoff R

Received 2 October 2014

Accepted for publication 17 November 2014

Published 9 February 2015 Volume 2015:7 Pages 205—211


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Elie Al-Chaer

Risto Gjavotchanoff1,2

Department of Laboratory Medicine, Bodenseelabor, Hörbranz, Austria; 2Institute of Anatomy II, University of Jena, Jena University Hospital, Jena, Germany

Abstract: Diagnostic workup of endometriosis usually involves laparoscopic inspection and histological examination of biopsies. Unequivocal laboratory parameters for this ailment have not been available in routine diagnostic evaluations thus far. In this study, we examined urine concentrations of cytokeratin 19 (CYFRA 21-1), a structural protein specific for epithelia. We performed immunoassays for CYFRA 21-1 in urine samples from women afflicted with endometriosis throughout their menstrual cycle. We observed a significant increase in CYFRA 21-1 concentrations, corrected by creatinine levels, in the late follicular phase as compared with the level in healthy controls. We conclude that cyclically increased CYFRA 21-1 concentrations in urine could serve as a valuable noninvasive diagnostic parameter in the workup of clinically manifesting endometriosis.

Keywords: biomarkers, menstrual cycle, CYFRA 21-1, immunoassay, noninvasive diagnosis

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