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Current Perspectives on Neurostimulation for the Management of Chronic Low Back Pain: A Narrative Review

Authors Provenzano DA, Heller JA, Hanes MC

Received 18 October 2020

Accepted for publication 16 December 2020

Published 17 February 2021 Volume 2021:14 Pages 463—479

DOI https://doi.org/10.2147/JPR.S249580

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Robert B. Raffa


David A Provenzano,1,2 Jared A Heller,3 Michael C Hanes4

1Pain Diagnostics and Interventional Care, Sewickley, PA, USA; 2Western PA Surgery Center, Wexford, PA, USA; 3Washington & Jefferson College, Washington, PA, USA; 4Jax Spine & Pain Centers, Jacksonville, FL, USA

Correspondence: David A Provenzano
Pain Diagnostics and Interventional Care, 301 Ohio River Blvd Suite 203, Sewickley, PA, 15143, USA
Tel +1 412-221-7640
Fax +1 412-490-7640
Email davidprovenzano@hotmail.com

Abstract: Neurostimulation techniques for the treatment of chronic low back pain (LBP) have been rapidly evolving; however, questions remain as to which modalities provide the most efficacious and durable treatment for intractable axial symptoms. Modalities of spinal cord stimulation, such as traditional low-frequency paresthesia based, high-density or high dose (HD), burst, 10-kHz high-frequency therapy, closed-loop, and differential target multiplexed, have been limitedly studied to determine their efficacy for the treatment of axial LBP. In addition, stimulation methods that target regions other than the spinal cord, such as medial branch nerve stimulation of the multifidus muscles and the dorsal root ganglion may also be viable treatment options. Here, current scientific evidence behind neurostimulation techniques have been reviewed with a focus on the management of chronic axial LBP.

Keywords: spinal cord stimulation, chronic, axial, neuromodulation

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