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Current perspectives on intrathecal drug delivery

Authors Bottros M, Christo P

Received 24 March 2014

Accepted for publication 8 May 2014

Published 6 November 2014 Volume 2014:7 Pages 615—626


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Michael M Bottros,1 Paul J Christo2

1Division of Pain Medicine, Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, 2Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Abstract: Advances in intrathecal analgesia and intrathecal drug delivery systems have allowed for a range of medications to be used in the control of pain and spasticity. This technique allows for reduced medication doses that can decrease the side effects typically associated with oral or parenteral drug delivery. Recent expert panel consensus guidelines have provided care paths in the treatment of nociceptive, neuropathic, and mixed pain syndromes. While the data for pain relief, adverse effect reduction, and cost-effectiveness with cancer pain control are compelling, the evidence is less clear for noncancer pain, other than spasticity. Physicians should be aware of mechanical, pharmacological, surgical, and patient-specific complications, including possible granuloma formation. Newer intrathecal drug delivery systems may allow for better safety and quality of life outcomes.

Keywords: pain control, intrathecal analgesia, drug delivery systems

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